DB11363

GPTKB entity

Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvedBy gptkb:FDA
2017
gptkbp:ATCCode gptkb:A06AH05
gptkbp:bioavailability ~20%
gptkbp:brand gptkb:Symproic
gptkbp:CASNumber gptkb:864821-90-9
gptkbp:contraindication patients with known or suspected gastrointestinal obstruction
gptkbp:eliminationHalfLife 11 hours
gptkbp:excretion urine
feces
gptkbp:hasInChIKey gptkb:QJQYQKZDHGQXQJ-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C32H34N4O6
gptkbp:hasSMILES CC1=CC(=O)N(C2=CC=CC=C12)C3CCN(CC3)CC4=CC=C(C=C4)C(=O)N5CCN(CC5)C(=O)COC6=CC=CC=C6
https://www.w3.org/2000/01/rdf-schema#label DB11363
gptkbp:indication treatment of opioid-induced constipation in adults with chronic non-cancer pain
gptkbp:marketedAs gptkb:Shionogi_Inc.
gptkbp:mechanismOfAction peripherally-acting mu-opioid receptor antagonist
gptkbp:metabolism liver (CYP3A4)
gptkbp:molecularWeight 570.6 g/mol
gptkbp:name gptkb:Naldemedine
gptkbp:pregnancyCategory Not assigned (US FDA)
gptkbp:proteinBinding ~93%
gptkbp:PubChem_CID gptkb:DB11363
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
diarrhea
abdominal pain
gptkbp:status true
gptkbp:bfsParent gptkb:alectinib
gptkbp:bfsLayer 6