Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
Myeloproliferative neoplasm |
| gptkbp:abbreviation |
MF
|
| gptkbp:affectsOrgan |
gptkb:Bone_marrow
|
| gptkbp:cause |
Leukemia
Portal hypertension Extramedullary hematopoiesis |
| gptkbp:causedBy |
gptkb:JAK2_mutation
CALR mutation MPL mutation |
| gptkbp:characterizedBy |
Fibrosis of bone marrow
|
| gptkbp:complication |
Infections
Bleeding Thrombosis |
| gptkbp:diagnosedBy |
Blood test
Bone marrow biopsy |
| gptkbp:firstDescribed |
1879
|
| gptkbp:hasEpidemiology |
Affects 1-2 per 100,000 per year
|
| gptkbp:hasMedianAgeOfOnset |
60 years
|
| gptkbp:hasOrphanetID |
ORPHA:732
|
| https://www.w3.org/2000/01/rdf-schema#label |
Myelofibrosis
|
| gptkbp:ICD-10_code |
D47.4
|
| gptkbp:inheritance |
Sporadic
|
| gptkbp:MeSH_ID |
D009196
|
| gptkbp:mortalityRate |
High in advanced stages
|
| gptkbp:OMIM |
254450
|
| gptkbp:pathology |
Leukoerythroblastosis
Megakaryocyte proliferation Reticulin fibrosis |
| gptkbp:prevalence |
Rare
|
| gptkbp:prognosis |
Variable
|
| gptkbp:riskFactor |
Male sex
Older age Exposure to toxins |
| gptkbp:subclassOf |
Chronic myeloproliferative disorder
|
| gptkbp:symptom |
gptkb:anemia
Weight loss Fatigue Splenomegaly Night sweats Bone pain |
| gptkbp:synonym |
Agnogenic myeloid metaplasia
Chronic idiopathic myelofibrosis Primary myelofibrosis |
| gptkbp:treatment |
gptkb:Hydroxyurea
Ruxolitinib Allogeneic stem cell transplantation Fedratinib |
| gptkbp:bfsParent |
gptkb:Elliptocytes
|
| gptkbp:bfsLayer |
8
|