Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:antibiotic
natural product antineoplastic agent |
| gptkbp:ATCCode |
L01DC03
|
| gptkbp:brand |
gptkb:Mitozytrex
gptkb:Mutamycin |
| gptkbp:CASNumber |
50-07-7
|
| gptkbp:category |
antitumor antibiotics
quinone antibiotics |
| gptkbp:chemicalFormula |
C15H18N4O5
|
| gptkbp:color |
blue-violet crystals
|
| gptkbp:contraindication |
pregnancy
severe bone marrow depression |
| gptkbp:discoveredBy |
1956
Kazuo Hata |
| gptkbp:drugbank_ID |
DB00305
|
| gptkbp:drugClass |
antineoplastic agent
|
| gptkbp:eliminationHalfLife |
50 minutes
|
| gptkbp:excretion |
urine
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mitomycin
|
| gptkbp:IUPACName |
(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-1,1a,2,8,8a,8b-hexahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7,9(6H)-trione
|
| gptkbp:KEGGID |
D00455
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
DNA crosslinking
|
| gptkbp:meltingPoint |
90–94 °C
|
| gptkbp:MeSH_ID |
D008937
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
334.33 g/mol
|
| gptkbp:origin |
bacterial fermentation
|
| gptkbp:pregnancyCategory |
D (US)
|
| gptkbp:producedBy |
gptkb:Streptomyces_caespitosus
|
| gptkbp:PubChem_CID |
5542
5746 CHEBI:17397 |
| gptkbp:routeOfAdministration |
intravenous
intravesical |
| gptkbp:sideEffect |
nausea
vomiting bone marrow suppression kidney toxicity lung toxicity |
| gptkbp:solubility |
slightly soluble
|
| gptkbp:UNII |
UAN7V32PQD
|
| gptkbp:usedFor |
pancreatic cancer
bladder cancer cancer chemotherapy gastric cancer anal cancer |
| gptkbp:bfsParent |
gptkb:Streptomyces_species
|
| gptkbp:bfsLayer |
6
|