Mitomycin

URI: https://gptkb.org/entity/Mitomycin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:natural_product gptkb:antineoplastic_agent gptkb:antibiotic
gptkbp:ATCCode	L01DC03
gptkbp:brand	gptkb:Mitozytrex gptkb:Mutamycin
gptkbp:CASNumber	50-07-7
gptkbp:category	antitumor antibiotics quinone antibiotics
gptkbp:chemicalFormula	C15H18N4O5
gptkbp:color	blue-violet crystals
gptkbp:contraindication	pregnancy severe bone marrow depression
gptkbp:discoveredBy	1956 Kazuo Hata
gptkbp:drugbank_ID	DB00305
gptkbp:drugClass	gptkb:antineoplastic_agent
gptkbp:eliminationHalfLife	50 minutes
gptkbp:excretion	urine
gptkbp:IUPACName	(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-1,1a,2,8,8a,8b-hexahydroazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7,9(6H)-trione
gptkbp:KEGGID	D00455
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	DNA crosslinking
gptkbp:meltingPoint	90–94 °C
gptkbp:MeSH_ID	D008937
gptkbp:metabolism	liver
gptkbp:molecularWeight	334.33 g/mol
gptkbp:origin	bacterial fermentation
gptkbp:pregnancyCategory	D (US)
gptkbp:producedBy	gptkb:Streptomyces_caespitosus
gptkbp:PubChem_CID	5542 5746 CHEBI:17397
gptkbp:routeOfAdministration	intravenous intravesical
gptkbp:sideEffect	nausea vomiting bone marrow suppression kidney toxicity lung toxicity
gptkbp:solubility	slightly soluble
gptkbp:UNII	UAN7V32PQD
gptkbp:usedFor	gptkb:bladder_cancer pancreatic cancer cancer chemotherapy gastric cancer anal cancer
gptkbp:bfsParent	gptkb:Asta_Medica
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Mitomycin