Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
|
| gptkbp:application |
asymmetric synthesis
synthesis of natural products synthesis of pharmaceuticals |
| gptkbp:category |
carbon-carbon bond forming reaction
|
| gptkbp:commonAcceptors |
α,β-unsaturated aldehydes
α,β-unsaturated esters α,β-unsaturated ketones |
| gptkbp:commonReagents |
amines
enolates nitroalkanes thiols β-dicarbonyl compounds |
| gptkbp:firstDescribed |
1887
|
| gptkbp:generalEquation |
Nu− + CH2=CH–C(O)R → Nu–CH2–CH2–C(O)R
|
| https://www.w3.org/2000/01/rdf-schema#label |
Michael addition
|
| gptkbp:involves |
enolate
α,β-unsaturated carbonyl compound |
| gptkbp:mechanismOfAction |
conjugate addition
|
| gptkbp:namedAfter |
gptkb:Arthur_Michael
|
| gptkbp:product |
1,5-dicarbonyl compound
|
| gptkbp:relatedTo |
gptkb:Robinson_annulation
gptkb:Aldol_reaction gptkb:Mannich_reaction |
| gptkbp:type |
nucleophilic addition
|
| gptkbp:usedIn |
organic synthesis
|
| gptkbp:bfsParent |
gptkb:Organic_Chemistry
|
| gptkbp:bfsLayer |
6
|