Statements (103)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:component |
RNA polymerase II transcription machinery
|
| gptkbp:composedOf |
gptkb:CCNC
gptkb:MED23 MED1 CDK8 MED10 MED11 MED12 MED12L MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7 MED8 MED9 |
| gptkbp:determines |
cryo-electron microscopy
|
| gptkbp:discoveredBy |
gptkb:Roger_D._Kornberg
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodedBy |
MED genes
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
transcription regulation
|
| gptkbp:GO_term |
GO:0016592
|
| gptkbp:hasSubcomplex |
CDK8 module
core Mediator head module middle module tail module |
| https://www.w3.org/2000/01/rdf-schema#label |
Mediator complex
|
| gptkbp:interactsWith |
gptkb:RNA_polymerase_II
transcription factors |
| gptkbp:involvedIn |
gptkb:disease
cell differentiation development signal transduction |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
intellectual disability developmental disorders |
| gptkbp:PDB |
5U0S
6H02 6Y9L 7B3P 7B3Q 7B3R 7B3S 7B3T 7B3U 7B3V 7B3W 7B3X 7B3Y 7B3Z 7B40 7B41 7B42 7B43 7B44 7B45 7B46 7B47 7B48 7B49 7B4A 7B4B 7B4C 7B4D 7B4E 7B4F 7B4G 7B4H 7B4I 7B4J 7B4K 7B4L 7B4M 7B4N 7B4O 7B4P |
| gptkbp:regulates |
gene expression
|
| gptkbp:relatedTo |
transcription coactivator
|
| gptkbp:requires |
transcription initiation
|
| gptkbp:UniProtID |
Q15648
|
| gptkbp:bfsParent |
gptkb:POLR2A_gene
gptkb:Drosophila_Nipped-B |
| gptkbp:bfsLayer |
7
|