|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
calcium-calmodulin complex
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:acute_respiratory_distress_syndrome
asthma
inflammatory bowel disease
|
|
gptkbp:cofactor
|
gptkb:ATP
Mg2+
|
|
gptkbp:component
|
gptkb:cytoplasm
|
|
gptkbp:domain
|
kinase domain
actin-binding domain
calmodulin-binding domain
|
|
gptkbp:EC_number
|
2.7.11.18
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
cardiac muscle
smooth muscle
|
|
gptkbp:fullName
|
gptkb:myosin_light-chain_kinase
|
|
gptkbp:function
|
myosin-light-chain kinase activity
phosphorylates myosin light chains
|
|
gptkbp:gene
|
gptkb:MYLK
|
|
gptkbp:GOProcess
|
regulation of smooth muscle contraction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MLCK
|
|
gptkbp:inhibitedBy
|
gptkb:ML-7
gptkb:ML-9
gptkb:wortmannin
gptkb:KN-93
MLCK inhibitors
|
|
gptkbp:locatedOnChromosome
|
3q21.1
|
|
gptkbp:molecularWeight
|
210 kDa (long isoform)
|
|
gptkbp:orthologInMouse
|
gptkb:Mylk
|
|
gptkbp:orthologInZebrafish
|
mylk1
|
|
gptkbp:PDB
|
2X4F
|
|
gptkbp:phosphorylates
|
Ser19 of myosin light chain
|
|
gptkbp:regulates
|
autoinhibition
phosphorylation
proteolysis
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
gptkb:Reactome
|
|
gptkbp:role
|
muscle contraction
|
|
gptkbp:structure
|
multi-domain protein
|
|
gptkbp:substrate
|
myosin regulatory light chain
|
|
gptkbp:UniProtID
|
gptkb:Q15746
|
|
gptkbp:bfsParent
|
gptkb:myosin_light-chain_kinase
|
|
gptkbp:bfsLayer
|
6
|