|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:binds
|
operator region of lac operon
|
|
gptkbp:category
|
operon model
transcriptional regulation
repressor protein
bacterial proteins
prokaryotic gene regulation
|
|
gptkbp:decommissioned
|
allolactose
IPTG
|
|
gptkbp:discoveredBy
|
gptkb:François_Jacob
gptkb:Jacques_Monod
|
|
gptkbp:discoveredIn
|
1961
|
|
gptkbp:domain
|
DNA-binding domain
core domain
tetramerization domain
|
|
gptkbp:encodedBy
|
gptkb:lacI_gene
|
|
gptkbp:foundIn
|
gptkb:Bacteria
|
|
gptkbp:function
|
prevents transcription in absence of lactose
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lac repressor
|
|
gptkbp:inhibitedBy
|
lactose
allolactose
transcription of lac operon
IPTG
|
|
gptkbp:locatedOnChromosome
|
upstream of lac operon
|
|
gptkbp:mechanismOfAction
|
negative regulation
|
|
gptkbp:molecularWeight
|
154 kDa
|
|
gptkbp:organism
|
gptkb:Bacteria
|
|
gptkbp:PDB
|
gptkb:1LBI
|
|
gptkbp:regulates
|
gptkb:lac_operon
gptkb:lacY_gene
lacZ gene
lacA gene
|
|
gptkbp:response
|
allolactose
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:usedIn
|
molecular biology research
gene expression studies
inducible expression systems
|
|
gptkbp:bfsParent
|
gptkb:lacI
gptkb:Repressor
|
|
gptkbp:bfsLayer
|
7
|