Statements (70)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:KRAS
|
| gptkbp:affects |
Ras signaling pathway
|
| gptkbp:analyzes |
cancer biology
therapeutic targets therapeutic resistance novel treatments |
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:caused_by |
uncontrolled cell growth
|
| gptkbp:discovered_by |
human cancer cells
|
| gptkbp:established |
targeted therapy
|
| gptkbp:examines |
molecular diagnostics
therapeutic strategies diagnostic purposes biomarker studies retrospective studies prognostic value |
| gptkbp:genetic_diversity |
missense mutation
|
| https://www.w3.org/2000/01/rdf-schema#label |
KRAS G12 V
|
| gptkbp:influences |
tumor microenvironment
|
| gptkbp:is_a |
gptkb:Ninjutsu
|
| gptkbp:is_aimed_at |
KRAS inhibitors
combination therapies |
| gptkbp:is_analyzed_in |
molecular profiling
mutation frequency mutation impact |
| gptkbp:is_associated_with |
cell cycle dysregulation
tumorigenesis immune evasion chemotherapy resistance resistance to therapies |
| gptkbp:is_characterized_by |
valine substitution
|
| gptkbp:is_considered |
personalized medicine
treatment response treatment planning |
| gptkbp:is_evaluated_by |
clinical settings
clinical outcomes therapeutic efficacy |
| gptkbp:is_found_in |
various cancers
|
| gptkbp:is_involved_in |
cell proliferation
cellular signaling |
| gptkbp:is_linked_to |
cellular metabolism
disease progression tumor heterogeneity metastasis poor prognosis invasive cancer behavior |
| gptkbp:is_monitored_by |
treatment outcomes
patient samples tumor samples |
| gptkbp:is_often_used_in |
gptkb:healthcare_organization
tumors |
| gptkbp:is_part_of |
gptkb:KRAS_gene
cancer research initiatives cancer genomics oncogenic signaling cancer pathways |
| gptkbp:is_popular_in |
high in pancreatic ductal adenocarcinoma
|
| gptkbp:is_recognized_by |
next-generation sequencing
|
| gptkbp:is_studied_in |
biomarker discovery
clinical trials cancer prevention strategies drug resistance mechanisms preclinical models experimental models |
| gptkbp:location |
codon 12
|
| gptkbp:recognizes |
genetic testing
|
| gptkbp:reports_to |
gptkb:literary_work
|
| gptkbp:research_focus |
gptkb:healthcare_organization
|