Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Iclusig
gptkb:Avapritinib |
| gptkbp:affects |
tyrosine kinase activity
|
| gptkbp:analyzes |
animal models
targeted therapies therapeutic targets biomarker potential |
| gptkbp:associated_with |
gptkb:healthcare_organization
Gastrointestinal stromal tumors mastocytosis |
| gptkbp:can_lead_to |
tumor growth
|
| gptkbp:caused_by |
gain-of-function
|
| gptkbp:descendant |
in some cases
|
| gptkbp:examines |
survival rates
clinical outcomes molecular studies |
| gptkbp:has_influence_on |
treatment response
|
| https://www.w3.org/2000/01/rdf-schema#label |
KIT mutations
|
| gptkbp:is_aimed_at |
gptkb:imatinib
gptkb:sunitinib gptkb:regorafenib |
| gptkbp:is_analyzed_in |
longitudinal studies
pathology reports mutation frequency |
| gptkbp:is_associated_with |
disease progression
resistance to therapy |
| gptkbp:is_characterized_by |
gptkb:municipality
|
| gptkbp:is_considered |
driver mutations
a focus of ongoing research. important in oncology research |
| gptkbp:is_discussed_in |
scientific reviews
|
| gptkbp:is_documented_in |
genetic databases
|
| gptkbp:is_evaluated_by |
clinical significance
|
| gptkbp:is_explored_in |
genetic counseling
|
| gptkbp:is_found_in |
exon 11
exon 9 exon 17 |
| gptkbp:is_linked_to |
increased cell proliferation
poor prognosis metastatic disease adverse effects of treatment increased survival of cancer cells |
| gptkbp:is_noted_for |
gptkb:academic_journal
|
| gptkbp:is_often_compared_to |
gptkb:Person
older adults |
| gptkbp:is_often_used_in |
certain cancers
|
| gptkbp:is_part_of |
molecular diagnostics
cancer genomics precision medicine approaches |
| gptkbp:is_recognized_by |
biopsy samples
|
| gptkbp:is_studied_in |
clinical trials
pharmacogenomics therapeutic resistance mechanisms therapeutic implications |
| gptkbp:is_subject_to |
regulatory approval
|
| gptkbp:is_tested_for |
research studies
|
| gptkbp:occurs_in |
somatic cells
germline |
| gptkbp:recognizes |
genetic testing
|
| gptkbp:reports_to |
case studies
|
| gptkbp:resulted_in |
abnormal cell signaling
|