Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
dephosphorylation
|
| gptkbp:alternativeName |
Potassium-chloride transporter member 5
SLC12A5 protein |
| gptkbp:associatedWith |
epilepsy
peripheral neuropathy |
| gptkbp:discoveredIn |
1996
|
| gptkbp:encodedBy |
SLC12A5 gene
|
| gptkbp:expressedIn |
central nervous system
|
| gptkbp:foundIn |
neurons
|
| gptkbp:function |
chloride transporter
maintains low intracellular chloride concentration |
| https://www.w3.org/2000/01/rdf-schema#label |
KCC2 protein
|
| gptkbp:inhibitedBy |
phosphorylation
|
| gptkbp:locale |
gptkb:plasma_membrane
|
| gptkbp:molecularWeight |
~140 kDa
|
| gptkbp:mutationAssociatedWith |
hyperexcitability
impaired inhibitory neurotransmission |
| gptkbp:orthologIn |
gptkb:human
gptkb:mouse right |
| gptkbp:regulates |
GABAergic inhibition
|
| gptkbp:requires |
neuronal development
|
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
12 transmembrane domains
|
| gptkbp:bfsParent |
gptkb:SLC12A5
|
| gptkbp:bfsLayer |
8
|