Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:SLC12A5
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:dysregulationAssociatedWith |
epilepsy
spasticity peripheral neuropathy |
| gptkbp:encodedBy |
SLC12A5 gene
|
| gptkbp:expressedIn |
central nervous system
|
| gptkbp:function |
gptkb:potassium-chloride_cotransporter
|
| https://www.w3.org/2000/01/rdf-schema#label |
KCC2
|
| gptkbp:locatedOnChromosome |
human chromosome 20q13.12
|
| gptkbp:location |
neuronal plasma membrane
|
| gptkbp:memberOf |
SLC12 family
|
| gptkbp:molecularWeight |
~140 kDa
|
| gptkbp:regulates |
phosphorylation
neurotrophic factors |
| gptkbp:requires |
neuronal inhibition
|
| gptkbp:role |
enables hyperpolarizing GABAergic transmission
maintains low intracellular chloride concentration |
| gptkbp:species |
gptkb:human
gptkb:mouse right |
| gptkbp:structure |
12 transmembrane domains
|
| gptkbp:bfsParent |
gptkb:SLC12A5
|
| gptkbp:bfsLayer |
8
|