Isavuconazole

URI: https://gptkb.org/entity/Isavuconazole

GPTKB entity

Predicate	Object
gptkbp:instanceOf	antiviral drug triazole antifungal
gptkbp:approvalYear	2015
gptkbp:approvedBy	gptkb:FDA gptkb:EMA
gptkbp:ATCCode	J02AC11
gptkbp:brand	gptkb:Cresemba
gptkbp:CASNumber	241479-67-4
gptkbp:category	antifungal agents triazoles
gptkbp:chemicalFormula	C22H17F2N5O
gptkbp:contraindication	strong CYP3A4 inducers familial short QT syndrome hypersensitivity to isavuconazole
gptkbp:developer	gptkb:Astellas_Pharma gptkb:Basilea_Pharmaceutica
gptkbp:drugInteraction	gptkb:phenytoin gptkb:rifampin gptkb:clarithromycin gptkb:ritonavir gptkb:carbamazepine gptkb:ketoconazole
gptkbp:eliminationHalfLife	130 hours
https://www.w3.org/2000/01/rdf-schema#label	Isavuconazole
gptkbp:IUPACName	(2R,3R)-3-[2-(2,5-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-1,2,4-triazol-1-yl]methyl]benzene
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits fungal cytochrome P450 enzyme 14α-demethylase
gptkbp:metabolism	liver
gptkbp:pregnancyCategory	C (US)
gptkbp:prodrugOf	isavuconazonium sulfate
gptkbp:proteinBinding	99%
gptkbp:routeOfAdministration	oral intravenous
gptkbp:sideEffect	nausea vomiting diarrhea hypokalemia increased liver enzymes
gptkbp:UNII	6MG7U6Q9ZT
gptkbp:usedFor	gptkb:mucormycosis gptkb:invasive_aspergillosis
gptkbp:bfsParent	gptkb:242138-07-4
gptkbp:bfsLayer	6