|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:associatedWith
|
gptkb:atopic_dermatitis
asthma
pulmonary fibrosis
allergic rhinitis
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:IL13_gene
|
|
gptkbp:enemyOf
|
gptkb:lebrikizumab
gptkb:tralokinumab
gptkb:dupilumab
|
|
gptkbp:Entrez_Gene_ID
|
3596
|
|
gptkbp:expressedIn
|
gptkb:basophils
gptkb:mast_cells
activated T cells
|
|
gptkbp:function
|
regulation of immune response
inhibition of inflammatory cytokines
promotion of IgE production
|
|
gptkbp:gene
|
gptkb:IL13
|
|
gptkbp:HGNC_ID
|
6014
|
|
gptkbp:homologInRat
|
gptkb:Il13
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Interleukin 13
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
immune system process
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
|
|
gptkbp:molecularWeight
|
13 kDa
|
|
gptkbp:OMIM
|
147683
|
|
gptkbp:orthologInMouse
|
gptkb:Il13
|
|
gptkbp:producedBy
|
gptkb:T_helper_2_cells
|
|
gptkbp:recipient
|
gptkb:IL-13_receptor_alpha_1
gptkb:IL-13_receptor_alpha_2
|
|
gptkbp:regulates
|
collagen synthesis
inflammatory response
antigen presentation
fibrosis
mucus production
airway hyperresponsiveness
eosinophil recruitment
macrophage activation
B cell maturation
chemokine production
epithelial cell function
goblet cell hyperplasia
smooth muscle contractility
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:symbol
|
gptkb:IL-13
|
|
gptkbp:UniProtID
|
gptkb:P35225
|
|
gptkbp:bfsParent
|
gptkb:IL13
|
|
gptkbp:bfsLayer
|
6
|