Inosine-5'-monophosphate dehydrogenase 1, human

URI: https://gptkb.org/entity/Inosine-5'-monophosphate_dehydrogenase_1,_human
GPTKB entity
Statements (28)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:IMPDH_type_I
gptkb:IMPDH1
gptkbp:associatedWith gptkb:Leber_congenital_amaurosis
retinitis pigmentosa
gptkbp:biologicalProcess purine nucleotide biosynthetic process
gptkbp:cofactor NAD+
gptkbp:EC_number 1.1.1.205
gptkbp:encodedBy gptkb:IMPDH1_gene
gptkbp:Entrez_Gene_ID 3614
gptkbp:function catalyzes conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP)
https://www.w3.org/2000/01/rdf-schema#label Inosine-5'-monophosphate dehydrogenase 1, human
gptkbp:inhibitedBy gptkb:mycophenolic_acid
ribavirin
gptkbp:locatedOnChromosome 7q32.1
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight 58 kDa
gptkbp:OMIM 146690
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 1B3O
gptkbp:product gptkb:NADH
xanthosine monophosphate
gptkbp:structure homotetramer
gptkbp:substrate gptkb:inosine_monophosphate
gptkbp:tissue_specificity ubiquitous
gptkbp:UniProtID O43734
gptkbp:bfsParent gptkb:IMPH-HSA
gptkbp:bfsLayer 7