Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:affects |
isocitrate dehydrogenase gene
|
| gptkbp:associatedWith |
gptkb:acute_myeloid_leukemia
gptkb:rhabdomyosarcoma glioma |
| gptkbp:cause |
DNA hypermethylation phenotype
epigenetic dysregulation |
| gptkbp:commonIn |
lower-grade glioma
|
| gptkbp:detects |
DNA sequencing
immunohistochemistry |
| gptkbp:diagnosticMarkerFor |
gptkb:glioblastoma
|
| gptkbp:firstDescribed |
2008
|
| https://www.w3.org/2000/01/rdf-schema#label |
IDH mutation
|
| gptkbp:locatedOnChromosome |
IDH1: 2q34
IDH2: 15q26.1 |
| gptkbp:prognosticMarkerFor |
glioma
|
| gptkbp:rareIn |
primary glioblastoma
|
| gptkbp:result |
production of 2-hydroxyglutarate
|
| gptkbp:target |
gptkb:ivosidenib
gptkb:enasidenib |
| gptkbp:type |
IDH1 mutation
IDH2 mutation |
| gptkbp:bfsParent |
gptkb:High-grade_glioma
|
| gptkbp:bfsLayer |
8
|