|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:IDP
IDHM
NADP-IDH
isocitrate dehydrogenase 2 (NADP+)
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
glioma
D-2-hydroxyglutaric aciduria
|
|
gptkbp:biologicalProcess
|
tricarboxylic acid cycle
cellular response to oxidative stress
|
|
gptkbp:cofactor
|
NADP+
|
|
gptkbp:encodes
|
isocitrate dehydrogenase [NADP], mitochondrial
|
|
gptkbp:Entrez_Gene_ID
|
3418
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
|
|
gptkbp:fullName
|
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
|
|
gptkbp:function
|
catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate
isocitrate dehydrogenase (NADP+) activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:5383
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IDH2 gene
|
|
gptkbp:inhibitedBy
|
gptkb:enasidenib
AG-221
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
gptkb:15q26.1
|
|
gptkbp:location
|
mitochondrial matrix
|
|
gptkbp:mutationAssociatedWith
|
missense mutation
R140
R172
|
|
gptkbp:OMIM
|
147650
|
|
gptkbp:orthologInMouse
|
Idh2
|
|
gptkbp:pathway
|
tricarboxylic acid cycle
|
|
gptkbp:relatedEnzymeFamily
|
isocitrate dehydrogenase family
|
|
gptkbp:subcellularLocation
|
mitochondrion
|
|
gptkbp:UniProtID
|
P48735
|
|
gptkbp:bfsParent
|
gptkb:IDH1/2_mutation
gptkb:Maffucci_syndrome
|
|
gptkbp:bfsLayer
|
6
|