|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity
|
phospholipase activity
triglyceride lipase activity
|
|
gptkbp:alternativeName
|
gptkb:LIPC
HL
|
|
gptkbp:CASNumber
|
9001-62-1
|
|
gptkbp:cofactor
|
requires heparan sulfate proteoglycans
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:EC_number
|
3.1.1.3
|
|
gptkbp:expressedIn
|
decreased by estrogens
decreased by insulin
increased by androgens
increased by fasting
|
|
gptkbp:family
|
gptkb:carboxylesterase_family
|
|
gptkbp:function
|
hydrolyzes phospholipids
hydrolyzes triglycerides
modifies lipoproteins
|
|
gptkbp:gene
|
gptkb:LIPC
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hepatic Lipase
|
|
gptkbp:inhibitedBy
|
gptkb:orlistat
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15q21-q23_(human)
|
|
gptkbp:location
|
liver
surface of hepatocytes
|
|
gptkbp:metabolism
|
lipid metabolism
|
|
gptkbp:molecularWeight
|
~60 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause familial hepatic lipase deficiency
|
|
gptkbp:orthologIn
|
present in mammals
|
|
gptkbp:regulates
|
regulated by androgens
regulated by estrogens
regulated by hormones
regulated by insulin
regulated by nutritional status
|
|
gptkbp:role
|
associated with atherosclerosis
associated with metabolic syndrome
|
|
gptkbp:role_in_HDL_metabolism
|
converts HDL2 to HDL3
|
|
gptkbp:role_in_LDL_metabolism
|
converts IDL to LDL
|
|
gptkbp:role_in_VLDL_metabolism
|
removes triglycerides from VLDL remnants
|
|
gptkbp:secretes
|
secreted by liver
|
|
gptkbp:significance
|
marker for cardiovascular risk
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:substrate
|
gptkb:high-density_lipoprotein_(HDL)
gptkb:intermediate-density_lipoprotein_(IDL)
chylomicron remnants
|
|
gptkbp:tissue_specificity
|
mainly in liver
|
|
gptkbp:UniProtID
|
P11150
|
|
gptkbp:bfsParent
|
gptkb:HLP
|
|
gptkbp:bfsLayer
|
6
|