Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
craniofacial development
limb development vertebral identity |
| gptkbp:clusterNames |
gptkb:HOXA
gptkb:HOXB gptkb:HOXC gptkb:HOXD |
| gptkbp:conservedSequence |
homeodomain
|
| gptkbp:contains |
homeobox domain
|
| gptkbp:dysregulationLinkedTo |
gptkb:cancer
congenital malformations |
| gptkbp:encodes |
transcription factors
|
| gptkbp:evolvesFrom |
gene duplication
|
| gptkbp:expressedIn |
embryogenesis
colinear with chromosomal order |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
regulation of embryonic development
anterior-posterior axis patterning |
| https://www.w3.org/2000/01/rdf-schema#label |
HOX genes in vertebrates
|
| gptkbp:involvedIn |
apoptosis
cell differentiation cell proliferation organogenesis segmentation hematopoiesis neural tube patterning skeletal patterning spinal cord development hindbrain development genital tract development |
| gptkbp:locatedOn |
different chromosomes
|
| gptkbp:mutationAssociatedWith |
homeotic transformation
|
| gptkbp:numberOfClusters |
four
|
| gptkbp:numberOfGenes |
39 (in humans)
|
| gptkbp:organizedBy |
clusters
|
| gptkbp:orthologIn |
gptkb:Drosophila_melanogaster
Hox genes in invertebrates |
| gptkbp:regulates |
epigenetic mechanisms
retinoic acid chromatin remodeling microRNAs downstream target genes body plan specification |
| gptkbp:studiedIn |
gptkb:meat
gptkb:mouse gptkb:zebrafish |
| gptkbp:transcriptionFactorType |
homeodomain protein
|
| gptkbp:bfsParent |
gptkb:Ultrabithorax_gene
|
| gptkbp:bfsLayer |
8
|