Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
DNA-dependent DNA synthesis
RNA-dependent DNA synthesis |
| gptkbp:determines |
X-ray crystallography
|
| gptkbp:discoveredIn |
1970
|
| gptkbp:EC_number |
2.7.7.49
|
| gptkbp:encodedBy |
gptkb:pol_gene
|
| gptkbp:familyMember |
reverse transcriptases
|
| gptkbp:form |
heterodimer
|
| gptkbp:foundIn |
gptkb:HIV
|
| gptkbp:function |
reverse transcription
|
| gptkbp:GO_term |
GO:0003964
|
| gptkbp:hasActivity |
RNA-dependent DNA polymerase activity
RNase H activity |
| https://www.w3.org/2000/01/rdf-schema#label |
HIV reverse transcriptase
|
| gptkbp:inhibitedBy |
non-nucleoside reverse transcriptase inhibitors
nucleoside reverse transcriptase inhibitors |
| gptkbp:molecularWeight |
~120 kDa
|
| gptkbp:mutationAssociatedWith |
drug resistance
|
| gptkbp:PDB |
1REV
|
| gptkbp:presentIn |
gptkb:HIV-1
gptkb:HIV-2 |
| gptkbp:requires |
HIV replication
|
| gptkbp:subunit |
p51
p66 |
| gptkbp:target |
antiretroviral drugs
|
| gptkbp:usedIn |
molecular biology research
|
| gptkbp:bfsParent |
gptkb:RNAse_H
|
| gptkbp:bfsLayer |
7
|