Glycogen debranching enzyme

URI: https://gptkb.org/entity/Glycogen_debranching_enzyme
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activity hydrolysis of alpha-1,6-glycosidic bonds
transfer of alpha-1,4-glucosyl units
gptkbp:alternativeName gptkb:GDE
4-alpha-glucanotransferase
amylo-1,6-glucosidase
gptkbp:associatedWith gptkb:Cori_disease
gptkb:Forbes_disease
gptkbp:cofactor none required
gptkbp:deficiencyCauses Glycogen storage disease type III
gptkbp:EC_number 2.4.1.25
3.2.1.33
gptkbp:expressedIn gptkb:skeletal_muscle
gptkb:kidney
liver
gptkbp:firstDescribed 1950s
gptkbp:foundIn gptkb:Bacteria
animals
fungi
gptkbp:function catalyzes the removal of branches from glycogen
gptkbp:gene gptkb:AGL
gptkbp:hasActivity glucosidase
glucosyltransferase
https://www.w3.org/2000/01/rdf-schema#label Glycogen debranching enzyme
gptkbp:human_gene_symbol gptkb:AGL
gptkbp:involves glycogenolysis
gptkbp:locatedOnChromosome 1p21.2
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight ~175 kDa
gptkbp:OMIM 610860
gptkbp:orthologInMouse Agl
gptkbp:orthologInYeast GDB1
gptkbp:pathway carbohydrate metabolism
gptkbp:PDB 2Q2M
gptkbp:product glucose
limit dextrin
gptkbp:reviewedBy gptkb:Journal_of_Biological_Chemistry
gptkb:Biochemical_Journal
gptkbp:structure single polypeptide chain
gptkbp:substrate gptkb:glycogen
gptkbp:UniProtID gptkb:P35573
gptkbp:bfsParent gptkb:GDT
gptkbp:bfsLayer 7