Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein conformation
|
| gptkbp:activatedBy |
downstream effectors
|
| gptkbp:associatedWith |
cell proliferation
oncogenesis |
| gptkbp:bindsMolecule |
gptkb:GTP
|
| gptkbp:conducts |
conformational change
|
| gptkbp:detects |
pull-down assays
|
| gptkbp:form |
gptkb:Ras_protein
|
| gptkbp:hasMolecularState |
active
|
| gptkbp:hasMutationImplication |
gptkb:cancer
|
| gptkbp:hasSwitchRegion |
Switch I
Switch II |
| https://www.w3.org/2000/01/rdf-schema#label |
GTP-bound Ras
|
| gptkbp:hydrolyzes |
GTP to GDP
|
| gptkbp:involvedIn |
cell signaling
|
| gptkbp:locale |
gptkb:plasma_membrane
|
| gptkbp:recognizedBy |
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs) |
| gptkbp:regulates |
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway |
| gptkbp:target |
drug development
|
| gptkbp:bfsParent |
gptkb:Ras-binding_domain
|
| gptkbp:bfsLayer |
6
|