Friedel–Crafts acylation of benzene
GPTKB entity
Statements (20)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
|
| gptkbp:application |
synthesis of aromatic ketones
|
| gptkbp:byproduct |
hydrogen chloride
|
| gptkbp:catalyzes |
gptkb:AlCl3
|
| gptkbp:discoveredIn |
1877
|
| https://www.w3.org/2000/01/rdf-schema#label |
Friedel–Crafts acylation of benzene
|
| gptkbp:limitation |
deactivated by strong electron-withdrawing groups
does not work with nitrobenzene polyacylation is less likely than in alkylation |
| gptkbp:mechanismOfAction |
formation of acylium ion
|
| gptkbp:namedAfter |
gptkb:James_Crafts
gptkb:Charles_Friedel |
| gptkbp:product |
aryl ketone
|
| gptkbp:reactant |
gptkb:aluminum_chloride
benzene acyl chloride |
| gptkbp:solvent |
dichloromethane
|
| gptkbp:type |
gptkb:electrophilic_aromatic_substitution
|
| gptkbp:bfsParent |
gptkb:Friedel–Crafts_reaction
|
| gptkbp:bfsLayer |
7
|