Fexofenadine

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
antihistamine
gptkbp:approvalYear 1996
gptkbp:ATCCode gptkb:R06AX26
gptkbp:bioavailability 30% to 41%
gptkbp:brand gptkb:Allegra
Telfast
Fexodane
gptkbp:CASNumber 153439-40-8
gptkbp:category second-generation antihistamine
gptkbp:chemicalFormula C32H39NO4
gptkbp:contraindication hypersensitivity to fexofenadine
gptkbp:developedBy terfenadine
gptkbp:discoveredBy gptkb:Marion_Merrell_Dow
gptkbp:eliminationHalfLife 14 hours
gptkbp:excretion urine
feces
gptkbp:form gptkb:tablet
oral suspension
dispersible tablet
https://www.w3.org/2000/01/rdf-schema#label Fexofenadine
gptkbp:interactsWith gptkb:erythromycin
gptkb:ketoconazole
antacids containing aluminum or magnesium
gptkbp:isomerOf (S)-fexofenadine
gptkbp:legalStatus prescription-only (in some countries)
over-the-counter (in many countries)
gptkbp:marketedAs gptkb:United_States
gptkbp:mechanismOfAction selective peripheral H1 receptor antagonist
gptkbp:meltingPoint 195–197 °C
gptkbp:metabolism minimal
gptkbp:notableFor non-sedating antihistamine
gptkbp:pregnancyCategory C (US)
gptkbp:prescribes adults
children
elderly
gptkbp:proteinBinding 60% to 70%
gptkbp:PubChem_CID 3348
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
dizziness
fatigue
headache
drowsiness (rare)
gptkbp:UNII K4RWD5W2EU
gptkbp:usedFor allergic rhinitis
chronic urticaria
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Antihistamines_for_systemic_use
gptkb:Allegra
gptkbp:bfsLayer 7