Statements (74)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:affects |
immune response
patient quality of life treatment response complement system visual acuity patient prognosis |
| gptkbp:applies_to |
clinical trials
personalized medicine therapeutic interventions epidemiological studies public health research |
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:can_be |
altered immune function
protein misfolding |
| gptkbp:can_lead_to |
renal impairment
systemic complications vascular complications atypical hemolytic uremic syndrome thrombotic microangiopathy clinical complications complement dysregulation |
| gptkbp:caused_by |
glomerulonephritis
|
| gptkbp:contribution |
chronic inflammation
|
| gptkbp:descendant |
autosomal dominant inheritance
|
| gptkbp:focuses_on |
molecular genetics research
|
| gptkbp:has_influence_on |
treatment outcomes
|
| https://www.w3.org/2000/01/rdf-schema#label |
Factor H mutations
|
| gptkbp:influence |
therapeutic strategies
inflammatory response disease management strategies research funding priorities |
| gptkbp:is_analyzed_in |
genomic sequencing
|
| gptkbp:is_associated_with |
gptkb:systemic_lupus_erythematosus
chronic kidney disease increased healthcare costs therapeutic outcomes increased risk of infections increased morbidity increased complement activation increased susceptibility to disease |
| gptkbp:is_characterized_by |
single nucleotide polymorphisms
functional assays clinical phenotypes |
| gptkbp:is_essential_for |
clinical diagnostics
understanding genetic predisposition understanding disease pathology |
| gptkbp:is_found_in |
various populations
|
| gptkbp:is_involved_in |
disease mechanisms
autoimmune disorders pathogenesis of diseases |
| gptkbp:is_linked_to |
gptkb:psychologist
complement-mediated diseases genetic counseling needs complement component deficiencies complement factor H protein dysfunction complement system disorders complement-mediated pathology |
| gptkbp:is_recognized_by |
population studies
familial studies |
| gptkbp:is_studied_in |
animal models
biomarker discovery risk assessment genetic research biochemical assays therapeutic development. gene therapy potential |
| gptkbp:recognizes |
genetic testing
|
| gptkbp:resulted_in |
decreased regulation of complement activation
|
| gptkbp:significance |
clinical research
healthcare policy discussions translational research |
| gptkbp:bfsParent |
gptkb:Atypical_Hemolytic_Uremic_Syndrome
|
| gptkbp:bfsLayer |
8
|