Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
bleeding disorder |
| gptkbp:alsoKnownAs |
gptkb:hemophilia_C
gptkb:Factor_XI_deficiency gptkb:Rosenthal_syndrome |
| gptkbp:category |
coagulation disorder
|
| gptkbp:causedBy |
deficiency of coagulation factor XI
|
| gptkbp:compatibleWith |
spontaneous joint bleeding (unlike hemophilia A and B)
|
| gptkbp:complication |
bleeding after dental procedures
bleeding after surgery |
| gptkbp:diagnosedBy |
factor XI assay
prolonged activated partial thromboplastin time (aPTT) |
| gptkbp:firstDescribed |
1953
Rosenthal et al. |
| gptkbp:frequency |
rare
|
| gptkbp:gene |
F11
|
| https://www.w3.org/2000/01/rdf-schema#label |
FXI deficiency
|
| gptkbp:ICD-10_code |
D68.2
|
| gptkbp:inheritance |
autosomal recessive
can be autosomal dominant (mild cases) |
| gptkbp:OMIM |
612416
|
| gptkbp:prevalence |
more common in Ashkenazi Jews
|
| gptkbp:symptom |
easy bruising
menorrhagia postoperative bleeding nosebleeds prolonged bleeding after injury |
| gptkbp:treatment |
antifibrinolytic agents
fresh frozen plasma factor XI concentrate |
| gptkbp:bfsParent |
gptkb:FXI
|
| gptkbp:bfsLayer |
7
|