Statements (47)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alsoKnownAs |
HNF-3B
|
| gptkbp:associatedWith |
gptkb:diabetes_mellitus
gptkb:congenital_hyperinsulinism |
| gptkbp:discoveredBy |
James Darnell and colleagues
|
| gptkbp:encodes |
FOXA2 protein
|
| gptkbp:Entrez_Gene_ID |
3170
ENSG00000125798 |
| gptkbp:expressedIn |
gptkb:cancer
liver pancreas |
| gptkbp:firstDescribed |
1990
|
| gptkbp:fullName |
Forkhead box protein A2
|
| gptkbp:function |
transcription factor
|
| gptkbp:hasDNABindingDomain |
forkhead domain
|
| gptkbp:hasTranscriptionFactorActivity |
sequence-specific DNA binding
|
| gptkbp:HGNC_ID |
HGNC:5021
|
| https://www.w3.org/2000/01/rdf-schema#label |
FOXA2
|
| gptkbp:importantFor |
embryonic development
lipid metabolism glucose homeostasis metabolic regulation bile acid homeostasis |
| gptkbp:locatedOnChromosome |
20p11
|
| gptkbp:memberOf |
forkhead box (FOX) family
|
| gptkbp:mutationAssociatedWith |
neonatal diabetes
pituitary hormone deficiency |
| gptkbp:OMIM |
600288
|
| gptkbp:orthologInMouse |
Foxa2
|
| gptkbp:orthologInZebrafish |
foxa2a
foxa2b |
| gptkbp:regulates |
gptkb:insulin_gene
glucagon gene albumin gene alpha-1-antitrypsin gene apolipoprotein genes endodermal cell fate gene expression in liver development gene expression in lung development gene expression in pancreas development hepatocyte differentiation lung epithelial cell differentiation pancreatic beta cell function surfactant protein genes |
| gptkbp:UniProtID |
Q9Y261
|
| gptkbp:bfsParent |
gptkb:Forkhead_box_(FOX)_protein_family
|
| gptkbp:bfsLayer |
7
|