Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:associatedWith |
gptkb:acute_myeloid_leukemia
myelodysplastic syndromes |
| gptkbp:cause |
increased cell proliferation
poor prognosis in AML |
| gptkbp:co-occursWith |
gptkb:NPM1_mutation
gptkb:DNMT3A_mutation |
| gptkbp:commonIn |
adult AML
pediatric AML |
| gptkbp:detects |
PCR
|
| gptkbp:firstDescribed |
1996
|
| gptkbp:frequencyInAML |
about 20-30%
|
| gptkbp:fullName |
FMS-like tyrosine kinase 3 internal tandem duplication mutation
|
| https://www.w3.org/2000/01/rdf-schema#label |
FLT3-ITD mutation
|
| gptkbp:impact |
overall survival in AML patients
relapse rate in AML |
| gptkbp:location |
juxtamembrane domain of FLT3 gene
|
| gptkbp:mutationAssociatedWith |
internal tandem duplication
|
| gptkbp:prognosticMarker |
yes
|
| gptkbp:regulates |
gptkb:FLT3
|
| gptkbp:result |
constitutive activation of FLT3 receptor
|
| gptkbp:target |
FLT3 inhibitors
|
| gptkbp:therapiesInclude |
gptkb:gilteritinib
gptkb:quizartinib gptkb:crenolanib gptkb:midostaurin |
| gptkbp:bfsParent |
gptkb:NPM1_mutation
|
| gptkbp:bfsLayer |
6
|