Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
epileptic syndrome
|
| gptkbp:abbreviation |
gptkb:LGS
|
| gptkbp:affects |
adolescents
children adults (rarely) |
| gptkbp:alsoKnownAs |
gptkb:Lennox-Gastaut_syndrome
|
| gptkbp:associatedWith |
intellectual disability
developmental delay behavioral problems |
| gptkbp:characterizedBy |
cognitive impairment
multiple seizure types slow spike-and-wave EEG pattern |
| gptkbp:commonSeizureTypes |
atonic seizures
myoclonic seizures generalized tonic-clonic seizures atypical absence seizures tonic seizures |
| gptkbp:EEGPattern |
slow spike-and-wave (1.5–2.5 Hz)
|
| gptkbp:etiology |
genetic causes
structural brain abnormalities diverse causes unknown in some cases |
| gptkbp:firstDescribed |
1966
|
| gptkbp:hasOrphanetID |
ORPHA:2386
|
| https://www.w3.org/2000/01/rdf-schema#label |
Epilepsy, Lennox-Gastaut
|
| gptkbp:ICD-10_code |
G40.4
|
| gptkbp:MeSH_ID |
D007566
|
| gptkbp:mortalityRate |
higher than other epilepsies
|
| gptkbp:namedAfter |
Henri Gastaut
William G. Lennox |
| gptkbp:OMIM |
606369
|
| gptkbp:onset |
childhood
between 3 and 5 years |
| gptkbp:prevalence |
rare
1-2% of all childhood epilepsies |
| gptkbp:prognosis |
often poor
seizures often persist into adulthood |
| gptkbp:riskFactor |
high
|
| gptkbp:seizureControl |
often difficult
|
| gptkbp:seizureFrequency |
frequent
|
| gptkbp:treatment |
gptkb:valproic_acid
gptkb:ketogenic_diet gptkb:vagus_nerve_stimulation gptkb:lamotrigine gptkb:topiramate gptkb:corpus_callosotomy cannabidiol antiepileptic drugs felbamate clobazam rufinamide |
| gptkbp:bfsParent |
gptkb:D004239
|
| gptkbp:bfsLayer |
8
|