|
gptkbp:instanceOf
|
gptkb:drug
ACE inhibitor
|
|
gptkbp:administeredBy
|
gptkb:tablet
oral solution
|
|
gptkbp:approvalYear
|
1984
|
|
gptkbp:ATCCode
|
C09AA02
|
|
gptkbp:bioavailability
|
60%
|
|
gptkbp:brand
|
gptkb:Renitec
gptkb:Vasotec
|
|
gptkbp:CASNumber
|
75847-73-3
|
|
gptkbp:category
|
prodrug
antihypertensive agent
carboxylate ester
dicarboxylic acid derivative
|
|
gptkbp:cause
|
dizziness
rash
renal impairment
elevated creatinine
|
|
gptkbp:chemicalFormula
|
C20H28N2O5
|
|
gptkbp:contraindication
|
pregnancy
history of angioedema
|
|
gptkbp:discoveredBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:discoveredIn
|
gptkb:United_States
|
|
gptkbp:eliminationHalfLife
|
11 hours (enalaprilat)
|
|
gptkbp:essentialMedicine
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:firstSynthesized
|
1978
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Enalapril
|
|
gptkbp:interactsWith
|
gptkb:NSAIDs
gptkb:aliskiren
lithium
diuretics
potassium-sparing diuretics
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits angiotensin-converting enzyme
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
376.447 g/mol
|
|
gptkbp:notRecommendedFor
|
pregnant women
patients with bilateral renal artery stenosis
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:prescribes
|
adults
children (in some cases)
|
|
gptkbp:prodrugOf
|
gptkb:enalaprilat
|
|
gptkbp:proteinBinding
|
50–60%
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
cough
hypotension
hyperkalemia
angioedema
|
|
gptkbp:usedFor
|
heart failure
hypertension
left ventricular dysfunction
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|