|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:administeredBy
|
ophthalmologist
|
|
gptkbp:approvalYear
|
2011
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
|
gptkbp:ATCCode
|
S01LA05
|
|
gptkbp:brand
|
gptkb:EYLEA
|
|
gptkbp:chemicalClass
|
gptkb:protein
|
|
gptkbp:contraindication
|
active intraocular inflammation
ocular infection
hypersensitivity to aflibercept
|
|
gptkbp:developedBy
|
gptkb:Bayer
gptkb:Regeneron_Pharmaceuticals
|
|
gptkbp:drugClass
|
anti-VEGF agent
|
|
gptkbp:form
|
intravitreal injection
solution for injection
|
|
gptkbp:genericName
|
gptkb:aflibercept
|
|
gptkbp:halfLife
|
~7 days (in vitreous)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EYLEA
|
|
gptkbp:indication
|
gptkb:diabetic_macular_edema
gptkb:neovascular_age-related_macular_degeneration
diabetic retinopathy
macular edema following retinal vein occlusion
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:macromoleculeType
|
gptkb:VEGF-A
gptkb:VEGF-B
gptkb:placental_growth_factor_(PlGF)
|
|
gptkbp:marketedAs
|
gptkb:Bayer
gptkb:Regeneron_Pharmaceuticals
|
|
gptkbp:mechanismOfAction
|
VEGF inhibitor
|
|
gptkbp:notRecommendedFor
|
pediatric patients
|
|
gptkbp:patentExpired
|
2023 (US)
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescribes
|
adults
|
|
gptkbp:product
|
recombinant fusion protein
|
|
gptkbp:routeOfAdministration
|
intravitreal injection
|
|
gptkbp:sideEffect
|
glaucoma
conjunctival hemorrhage
eye pain
increased intraocular pressure
vitreous detachment
endophthalmitis
retinal detachment
|
|
gptkbp:storage
|
2°C to 8°C
|
|
gptkbp:website
|
https://www.eylea.us/
|
|
gptkbp:bfsParent
|
gptkb:Regeneron
|
|
gptkbp:bfsLayer
|
6
|