Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:alsoKnownAs |
gptkb:EGFR_exon_20_T790M_mutation
|
| gptkbp:aminoAcidChange |
threonine to methionine at position 790
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
|
| gptkbp:category |
oncogenic mutation
|
| gptkbp:detects |
liquid biopsy
tissue biopsy |
| gptkbp:discoveredIn |
2005
|
| gptkbp:effect |
increases ATP affinity of EGFR
reduces inhibitor binding |
| gptkbp:foundIn |
gptkb:EGFR_gene
|
| https://www.w3.org/2000/01/rdf-schema#label |
EGFR T790M mutation
|
| gptkbp:locatedOnChromosome |
gptkb:7p11.2
|
| gptkbp:prevalenceInAcquiredResistance |
~50% of EGFR-mutant NSCLC cases
|
| gptkbp:resistantTo |
gptkb:erlotinib
gptkb:gefitinib gptkb:EGFR_tyrosine_kinase_inhibitors |
| gptkbp:significance |
guides targeted therapy selection
|
| gptkbp:target |
gptkb:osimertinib
|
| gptkbp:bfsParent |
gptkb:Tagrisso
|
| gptkbp:bfsLayer |
6
|