Statements (14)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:genetic_disorder
|
| gptkbp:affects |
exon 20
|
| gptkbp:aminoAcidChange |
threonine to methionine at position 790
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
|
| gptkbp:discoveredIn |
2005
|
| gptkbp:locatedIn |
gptkb:EGFR_gene
|
| gptkbp:mutationAssociatedWith |
gptkb:point_mutation
|
| gptkbp:resistantTo |
gptkb:EGFR_tyrosine_kinase_inhibitors
|
| gptkbp:significance |
acquired resistance
|
| gptkbp:target |
gptkb:osimertinib
rociletinib |
| gptkbp:bfsParent |
gptkb:EGFR_T790M_mutation
|
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
EGFR exon 20 T790M mutation
|