INS gene in humans
E481234
The INS gene in humans is the gene that produces insulin, a key hormone that regulates blood glucose levels and is central to the development of diabetes when dysfunctional.
All labels observed (1)
| Label | Occurrences |
|---|---|
| INS gene in humans canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4945899 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: INS gene in humans Context triple: [insulin, encodedBy, INS gene in humans]
-
A.
Gene
Gene is the given name of No Malice, the American rapper best known as one half of the hip hop duo Clipse.
-
B.
institute of genetics
The Institute of Genetics is an academic research and teaching unit specializing in genetic science within the Vetsuisse Faculty.
-
C.
Institute of Genetics
The Institute of Genetics is a specialized branch of Canada’s federal health research funding agency that supports and advances research in genetics and related biomedical fields.
-
D.
Human Genome Project
The Human Genome Project was an international scientific research initiative that successfully mapped and sequenced the entire human DNA genome, revolutionizing genetics and biomedical research.
-
E.
National Human Genome Research Institute
The National Human Genome Research Institute is a U.S. government biomedical research organization that leads and funds research on the structure, function, and impact of the human genome.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: INS gene in humans Target entity description: The INS gene in humans is the gene that produces insulin, a key hormone that regulates blood glucose levels and is central to the development of diabetes when dysfunctional.
-
A.
Gene
Gene is the given name of No Malice, the American rapper best known as one half of the hip hop duo Clipse.
-
B.
institute of genetics
The Institute of Genetics is an academic research and teaching unit specializing in genetic science within the Vetsuisse Faculty.
-
C.
Institute of Genetics
The Institute of Genetics is a specialized branch of Canada’s federal health research funding agency that supports and advances research in genetics and related biomedical fields.
-
D.
Human Genome Project
The Human Genome Project was an international scientific research initiative that successfully mapped and sequenced the entire human DNA genome, revolutionizing genetics and biomedical research.
-
E.
National Human Genome Research Institute
The National Human Genome Research Institute is a U.S. government biomedical research organization that leads and funds research on the structure, function, and impact of the human genome.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein-coding gene ⓘ |
| associatedWithDisease |
hyperinsulinemia
ⓘ
insulinoma ⓘ maturity-onset diabetes of the young ⓘ metabolic syndrome ⓘ neonatal diabetes mellitus ⓘ type 1 diabetes mellitus ⓘ type 2 diabetes mellitus ⓘ |
| associatedWithTrait |
fasting plasma glucose level
ⓘ
insulin secretion ⓘ insulin sensitivity ⓘ |
| biologicalProcess |
carbohydrate metabolism
ⓘ
glucose homeostasis ⓘ lipid metabolism ⓘ protein metabolism ⓘ regulation of blood glucose ⓘ |
| encodes |
insulin
ⓘ
preproinsulin ⓘ
linked to:
insulin
proinsulin ⓘ |
| expressedIn |
islets of Langerhans
ⓘ
pancreas ⓘ pancreatic beta cell ⓘ |
| foundInSpecies | Homo sapiens ⓘ |
| hasEnsemblID | ENSG00000254647 ⓘ |
| hasEntrezGeneID | 3630 ⓘ |
| hasHGNCID | 6081 ⓘ |
| hasPolymorphism | variable number tandem repeat at 5′ region ⓘ |
| hasStrandOrientation | plus strand ⓘ |
| hasUniProtID | P01308 ⓘ |
| locatedInChromosomalBand | 11p15.5 ⓘ |
| locatedOnChromosome | chromosome 11 ⓘ |
| memberOfPathway |
MAPK signaling pathway
ⓘ
PI3K-Akt signaling pathway ⓘ
linked to:
PI3K-AKT signaling pathway
insulin signaling pathway ⓘ |
| molecularFunction |
growth factor activity
ⓘ
hormone activity ⓘ |
| orthologOf |
mouse Ins2 gene
ⓘ
rat Ins1 gene ⓘ |
| polymorphismAssociatedWith |
birth weight variation
ⓘ
type 1 diabetes risk ⓘ |
| proteinProduct |
C-peptide
ⓘ
insulin A chain ⓘ
linked to:
insulin
insulin B chain ⓘ insulin precursor ⓘ |
| regulatedBy |
FOXA2 transcription factor
ⓘ
MAFA transcription factor ⓘ NEUROD1 transcription factor ⓘ PDX1 transcription factor ⓘ glucose ⓘ |
| transcriptProduces | INS mRNA ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: INS gene in humans Description of subject: The INS gene in humans is the gene that produces insulin, a key hormone that regulates blood glucose levels and is central to the development of diabetes when dysfunctional.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.