platelet-derived growth factor

E681666

Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.

All labels observed (10)

Label Occurrences
PDGF 1
PDGF-A chain 1
PDGF-B chain 1

How this entity was disambiguated

Statements (54)

Predicate Object
instanceOf cytokine
growth factor
mitogen
signaling protein
activates JAK-STAT signaling pathway
MAPK signaling pathway
PI3K-AKT signaling pathway
receptor tyrosine kinases
alternativeName PDGF
associatedWith atherosclerosis
cancer
diabetic retinopathy
fibrosis
idiopathic pulmonary fibrosis
pulmonary arterial hypertension
bindsTo PDGF receptor alpha
PDGF receptor beta
linked to: PDGFRβ
composedOf PDGF-A chain
PDGF-B chain
PDGF-C chain
PDGF-D chain
discoveredIn 1970s
encodedBy PDGFA gene
PDGFB gene
PDGFC gene
PDGFD gene
forms PDGF-AA dimer
PDGF-AB dimer
PDGF-BB dimer
PDGF-CC dimer
PDGF-DD dimer
foundIn platelet alpha granules
involvedIn embryonic development
tissue repair
wound healing
producedBy endothelial cells
fibroblasts
macrophages
platelets
smooth muscle cells
promotes chemotaxis of mesenchymal cells
pericyte recruitment
vascular remodeling
regulates angiogenesis
cell growth
cell migration
cell proliferation
stimulates extracellular matrix production
fibroblast proliferation
smooth muscle cell proliferation
targetCellType fibroblasts
glial cells
mesenchymal cells
smooth muscle cells

How these facts were elicited

Referenced by (10)

Full triples — surface form annotated when it differs from this entity's canonical label.

Carl-Henrik Heldin fieldOfWork platelet-derived growth factor
platelet-derived growth factor composedOf PDGF-A chain
linked to: platelet-derived growth factor
platelet-derived growth factor composedOf PDGF-B chain
linked to: platelet-derived growth factor
platelet-derived growth factor composedOf PDGF-C chain
linked to: platelet-derived growth factor
platelet-derived growth factor composedOf PDGF-D chain
linked to: platelet-derived growth factor
platelet-derived growth factor encodedBy PDGFA gene
linked to: platelet-derived growth factor
platelet-derived growth factor encodedBy PDGFB gene
linked to: platelet-derived growth factor
platelet-derived growth factor encodedBy PDGFC gene
linked to: platelet-derived growth factor
platelet-derived growth factor encodedBy PDGFD gene
linked to: platelet-derived growth factor
Power Data Grapple Fixture abbreviation PDGF
linked to: platelet-derived growth factor