CDK6
E564269
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
All labels observed (2)
| Label | Occurrences |
|---|---|
| CDK6 canonical | 2 |
| cyclin-dependent kinase 6 | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T6003525 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CDK6 Context triple: [Verzenio, targets, CDK6]
-
A.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
B.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
C.
CNK4
CNK4 is the ICAO airport code assigned to Parry Sound Area Municipal Airport in Ontario, Canada.
-
D.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
E.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CDK6 Target entity description: CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
A.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
B.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
C.
CNK4
CNK4 is the ICAO airport code assigned to Parry Sound Area Municipal Airport in Ontario, Canada.
-
D.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
E.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
cyclin-dependent kinase
ⓘ
human gene ⓘ protein kinase ⓘ |
| associatedWithDisease |
acute lymphoblastic leukemia
ⓘ
acute myeloid leukemia ⓘ breast cancer ⓘ glioblastoma ⓘ lymphoma ⓘ melanoma ⓘ non-small cell lung cancer ⓘ |
| belongsToPathway |
G1/S DNA damage checkpoint pathway
ⓘ
linked to:
DNA damage checkpoints
cell cycle pathway ⓘ p16INK4A-CDK4/6-RB pathway ⓘ |
| encodes |
cyclin-dependent kinase 6
ⓘ
linked to:
CDK6
|
| hasAlternativeName |
CDKN6
ⓘ
cell division protein kinase 6 ⓘ |
| hasBiologicalProcess |
B cell proliferation
ⓘ
G1 phase of mitotic cell cycle ⓘ G1/S transition of mitotic cell cycle ⓘ T cell differentiation ⓘ cell cycle progression ⓘ hematopoietic cell differentiation ⓘ regulation of cell proliferation ⓘ |
| hasCellularComponent |
cytoplasm
ⓘ
nucleus ⓘ |
| hasEntrezGeneID | 1021 ⓘ |
| hasEnzymeCommissionNumber | EC 2.7.11.22 ⓘ |
| hasGeneSymbol | CDK6 ⓘ |
| hasHGNCID | HGNC:1777 ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
cyclin-dependent protein serine/threonine kinase activity ⓘ protein serine/threonine kinase activity ⓘ |
| hasUniProtID | Q00534 ⓘ |
| inhibitedBy | CDK4/6 inhibitors ⓘ |
| interactsWith |
cyclin D1
ⓘ
cyclin D2 ⓘ cyclin D3 ⓘ |
| isDrugTargetOf |
abemaciclib
ⓘ
dalpiciclib ⓘ palbociclib ⓘ
linked to:
Ibrance
ribociclib ⓘ trilaciclib ⓘ |
| locatedOnChromosome | chromosome 7 ⓘ |
| locatedOnChromosomeBand | 7q21.2 ⓘ |
| organism | Homo sapiens ⓘ |
| phosphorylates |
RB1
ⓘ
retinoblastoma protein ⓘ |
| regulatedBy |
CDKN2A
ⓘ
linked to:
CDKN2A (p16INK4A)
CDKN2B ⓘ
linked to:
CDKN2B (p15INK4B)
p15INK4B ⓘ
linked to:
CDKN2B (p15INK4B)
p16INK4A ⓘ
linked to:
CDKN2A (p16INK4A)
|
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CDK6 Description of subject: CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.