DNA damage checkpoints
E1274898
UNEXPLORED
DNA damage checkpoints are cellular surveillance mechanisms that monitor and respond to DNA damage by halting cell cycle progression to allow repair and maintain genomic integrity.
All labels observed (2)
| Label | Occurrences |
|---|---|
| DNA damage checkpoints canonical | 1 |
| G1/S DNA damage checkpoint pathway | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T17549761 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: DNA damage checkpoints Context triple: [Leland H. Hartwell, hasResearchArea, DNA damage checkpoints]
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A.
PARP enzymes
PARP enzymes are a family of nuclear proteins that detect DNA damage and catalyze poly(ADP-ribosyl)ation of target proteins to regulate DNA repair, genomic stability, and cell death.
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B.
Cancer, Ageing and Somatic Mutation
Cancer, Ageing and Somatic Mutation is a research programme that investigates how genetic changes in cells drive cancer development and the biological processes of ageing.
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C.
Cellular Genetics
Cellular Genetics is a research programme at the Wellcome Sanger Institute focused on understanding how genetic variation and cellular processes interact to influence health and disease.
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D.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
The Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases is a research consortium focused on understanding how cellular stress mechanisms contribute to aging and age-related diseases to develop new therapeutic strategies.
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E.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: DNA damage checkpoints Target entity description: DNA damage checkpoints are cellular surveillance mechanisms that monitor and respond to DNA damage by halting cell cycle progression to allow repair and maintain genomic integrity.
-
A.
PARP enzymes
PARP enzymes are a family of nuclear proteins that detect DNA damage and catalyze poly(ADP-ribosyl)ation of target proteins to regulate DNA repair, genomic stability, and cell death.
-
B.
Cancer, Ageing and Somatic Mutation
Cancer, Ageing and Somatic Mutation is a research programme that investigates how genetic changes in cells drive cancer development and the biological processes of ageing.
-
C.
Cellular Genetics
Cellular Genetics is a research programme at the Wellcome Sanger Institute focused on understanding how genetic variation and cellular processes interact to influence health and disease.
-
D.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
The Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases is a research consortium focused on understanding how cellular stress mechanisms contribute to aging and age-related diseases to develop new therapeutic strategies.
-
E.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: DNA damage checkpoints