RB1
E1549318
UNEXPLORED
RB1 is a tumor suppressor protein that regulates the cell cycle by controlling the transition from G1 to S phase and is frequently inactivated in human cancers.
All labels observed (1)
| Label | Occurrences |
|---|---|
| RB1 canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690290 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: RB1 Context triple: [CDK4, substrate, RB1]
-
A.
Knudson
Knudson is a surname of Scandinavian origin that serves as a variant spelling of Knudsen.
-
B.
Cdh1
Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
-
C.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
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D.
LRP1
LRP1 is a multifunctional endocytic and signaling receptor involved in lipid metabolism, clearance of extracellular molecules, and modulation of neuronal and vascular processes.
-
E.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: RB1 Target entity description: RB1 is a tumor suppressor protein that regulates the cell cycle by controlling the transition from G1 to S phase and is frequently inactivated in human cancers.
-
A.
Knudson
Knudson is a surname of Scandinavian origin that serves as a variant spelling of Knudsen.
-
B.
Cdh1
Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
-
C.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
D.
LRP1
LRP1 is a multifunctional endocytic and signaling receptor involved in lipid metabolism, clearance of extracellular molecules, and modulation of neuronal and vascular processes.
-
E.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.