BTK
E561038
BTK (Bruton’s tyrosine kinase) is a key signaling enzyme in B cells and a major therapeutic target in certain blood cancers and autoimmune diseases.
All labels observed (4)
| Label | Occurrences |
|---|---|
| BTK canonical | 2 |
| BTK tyrosine kinase | 1 |
| Bruton’s tyrosine kinase | 1 |
| Cys481 of BTK | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6003728 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: BTK Context triple: [Loxo Oncology, drugTarget, BTK]
-
A.
Batta
Batta is an ethnic group indigenous to northeastern Nigeria, particularly associated with Adamawa State.
-
B.
Bt
Bt is the post-nominal abbreviation for a baronetcy title in the British honours system, indicating that the holder is a baronet.
-
C.
Batz
Batz is a German surname most notably associated with World War II Luftwaffe fighter ace Wilhelm Batz.
-
D.
Bax
Bax is a Dutch-American biophysical chemist renowned for pioneering the use of multidimensional nuclear magnetic resonance (NMR) spectroscopy to study the structure and dynamics of biological macromolecules.
-
E.
Baki
Baki was a prominent 16th-century Ottoman Turkish poet renowned for his refined ghazals and mastery of classical divan literature.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: BTK Target entity description: BTK (Bruton’s tyrosine kinase) is a key signaling enzyme in B cells and a major therapeutic target in certain blood cancers and autoimmune diseases.
-
A.
Batta
Batta is an ethnic group indigenous to northeastern Nigeria, particularly associated with Adamawa State.
-
B.
Bt
Bt is the post-nominal abbreviation for a baronetcy title in the British honours system, indicating that the holder is a baronet.
-
C.
Batz
Batz is a German surname most notably associated with World War II Luftwaffe fighter ace Wilhelm Batz.
-
D.
Bax
Bax is a Dutch-American biophysical chemist renowned for pioneering the use of multidimensional nuclear magnetic resonance (NMR) spectroscopy to study the structure and dynamics of biological macromolecules.
-
E.
Baki
Baki was a prominent 16th-century Ottoman Turkish poet renowned for his refined ghazals and mastery of classical divan literature.
- F. None of above. chosen
Statements (56)
| Predicate | Object |
|---|---|
| instanceOf |
Bruton’s tyrosine kinase
ⓘ
protein ⓘ |
| activatedBy |
SYK
ⓘ
Src family kinases ⓘ phosphorylation at Y551 ⓘ |
| associatedWithDisease |
Waldenström macroglobulinemia
ⓘ
X-linked agammaglobulinemia ⓘ autoimmune diseases ⓘ chronic lymphocytic leukemia ⓘ diffuse large B-cell lymphoma ⓘ mantle cell lymphoma ⓘ
linked to:
non-Hodgkin lymphoma
|
| belongsToFamily | Tec family kinases ⓘ |
| binds |
BLNK
ⓘ
PLCγ2 ⓘ phosphatidylinositol 3,4,5-trisphosphate ⓘ |
| chromosomalLocation | Xq21.3–Xq22 ⓘ |
| discoveredBy | Ogden Bruton ⓘ |
| encodedBy | BTK gene ⓘ |
| expressedIn |
B lymphocytes
ⓘ
mast cells ⓘ myeloid cells ⓘ platelets ⓘ |
| hasDomain |
Pleckstrin homology domain
ⓘ
SH2 domain ⓘ SH3 domain ⓘ Tec homology domain ⓘ tyrosine kinase domain ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
protein phosphorylation ⓘ protein tyrosine kinase activity ⓘ |
| hasMutationConsequence | loss-of-function mutations cause X-linked agammaglobulinemia ⓘ |
| inhibitedBy |
acalabrutinib
ⓘ
ibrutinib ⓘ
linked to:
Imbruvica
pirtobrutinib ⓘ spebrutinib ⓘ tirabrutinib ⓘ zanubrutinib ⓘ |
| isTherapeuticTargetIn |
B cell malignancies
ⓘ
Waldenström macroglobulinemia ⓘ autoimmune diseases ⓘ chronic lymphocytic leukemia ⓘ mantle cell lymphoma ⓘ |
| locatedIn |
cytoplasm
ⓘ
plasma membrane ⓘ |
| namedAfter | Ogden Bruton ⓘ |
| partOf |
B cell activation pathway
ⓘ
B cell receptor signaling pathway ⓘ |
| playsRoleIn |
B cell development
ⓘ
B cell differentiation ⓘ B cell maturation ⓘ B cell proliferation ⓘ B cell survival ⓘ MAPK pathway activation ⓘ NF-κB activation ⓘ calcium signaling in B cells ⓘ signal transduction ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: BTK Description of subject: BTK (Bruton’s tyrosine kinase) is a key signaling enzyme in B cells and a major therapeutic target in certain blood cancers and autoimmune diseases.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.