PLCγ2
E888597
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
All labels observed (5)
| Label | Occurrences |
|---|---|
| PLCγ2 canonical | 2 |
| PLC-gamma-2 | 1 |
| PLCG2 | 1 |
| PLCG2 gene | 1 |
| phospholipase C gamma 2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10837751 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: PLCγ2 Context triple: [Bruton tyrosine kinase, phosphorylates, PLCγ2]
-
A.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
-
B.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
C.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
D.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
E.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: PLCγ2 Target entity description: PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
A.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
-
B.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
C.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
D.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
E.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
- F. None of above. chosen
Statements (64)
| Predicate | Object |
|---|---|
| instanceOf |
phospholipase C isoform
ⓘ
protein ⓘ signal transduction protein ⓘ |
| activatedBy |
B cell receptor
ⓘ
Bruton tyrosine kinase ⓘ Fcγ receptor ⓘ Fcε receptor ⓘ
linked to:
CD23
GPVI collagen receptor ⓘ Syk tyrosine kinase ⓘ |
| alternativeName |
PLC-gamma-2
ⓘ
linked to:
PLCγ2
PLCG2 ⓘ
linked to:
PLCγ2
phospholipase C gamma 2 ⓘ
linked to:
PLCγ2
|
| associatedWith |
Alzheimer’s disease risk modulation
ⓘ
PLCG2-associated antibody deficiency and immune dysregulation ⓘ autoinflammatory disease ⓘ familial cold autoinflammatory syndrome 3 ⓘ immune deficiency ⓘ |
| biologicalProcess |
B cell receptor signaling pathway
ⓘ
Fc receptor signaling pathway ⓘ bone resorption ⓘ calcium ion mobilization ⓘ immune response ⓘ intracellular signal transduction ⓘ lymphocyte activation ⓘ mast cell activation ⓘ myeloid cell activation ⓘ natural killer cell activation ⓘ neutrophil activation ⓘ osteoclast differentiation ⓘ phosphoinositide signaling ⓘ platelet activation ⓘ receptor-mediated signaling ⓘ regulation of cytosolic calcium ion concentration ⓘ |
| catalyzes | hydrolysis of phosphatidylinositol 4,5-bisphosphate ⓘ |
| containsDomain |
C2 domain
ⓘ
EF-hand domain ⓘ PH domain ⓘ SH2 domain ⓘ SH3 domain ⓘ X catalytic domain ⓘ Y catalytic domain ⓘ |
| encodedBy |
PLCG2 gene
ⓘ
linked to:
PLCγ2
|
| expressedIn |
B cells
ⓘ
NK cells ⓘ mast cells ⓘ myeloid cells ⓘ platelets ⓘ |
| hasEnzymeCommissionNumber | EC 3.1.4.11 ⓘ |
| locatedIn |
cytoplasm
ⓘ
plasma membrane ⓘ |
| molecularFunction |
SH2 domain binding
ⓘ
SH3 domain binding ⓘ calcium ion binding ⓘ phosphatidylinositol binding ⓘ phosphatidylinositol phospholipase C activity ⓘ phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity ⓘ phospholipase C activity ⓘ |
| organism | Homo sapiens ⓘ |
| orthologOf | mouse Plcg2 ⓘ |
| produces |
diacylglycerol
ⓘ
inositol 1,4,5-trisphosphate ⓘ |
| upstreamOf |
MAPK cascade activation
ⓘ
NF-κB activation ⓘ protein kinase C activation ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: PLCγ2 Description of subject: PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: PLCγ2
linked to: PLCγ2
linked to: PLCγ2