chronic lymphocytic leukemia

E822402

hematologic malignancy leukemia lymphoproliferative disorder non-Hodgkin lymphoma

Chronic lymphocytic leukemia is a slow-growing cancer of the blood and bone marrow characterized by an overproduction of abnormal lymphocytes, most commonly affecting older adults.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (4)

Label	Occurrences
chronic lymphocytic leukemia canonical	9
small lymphocytic lymphoma	3
B-cell leukemia	1
CLL	1

How this entity was disambiguated

This entity first appeared as the object of triple T9807078 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: chronic lymphocytic leukemia
Context triple: [MabThera, indication, chronic lymphocytic leukemia]

A. CLL
CLL is the IATA airport code for Easterwood Airport, a regional airport serving College Station, Texas.
B. non-Hodgkin lymphoma
Non-Hodgkin lymphoma is a diverse group of blood cancers that originate in the lymphatic system from abnormal lymphocytes and can vary widely in aggressiveness and prognosis.
C. Hodgkin lymphoma
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, characterized by the presence of abnormal Reed–Sternberg cells and often affecting lymph nodes.
D. Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
E. Leukemia and Lymphoma Research
Leukemia and Lymphoma Research is a UK-based medical research charity dedicated to improving the diagnosis, treatment, and prevention of blood cancers such as leukemia and lymphoma.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: chronic lymphocytic leukemia
Target entity description: Chronic lymphocytic leukemia is a slow-growing cancer of the blood and bone marrow characterized by an overproduction of abnormal lymphocytes, most commonly affecting older adults.

A. CLL
CLL is the IATA airport code for Easterwood Airport, a regional airport serving College Station, Texas.
B. non-Hodgkin lymphoma
Non-Hodgkin lymphoma is a diverse group of blood cancers that originate in the lymphatic system from abnormal lymphocytes and can vary widely in aggressiveness and prognosis.
C. Hodgkin lymphoma
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, characterized by the presence of abnormal Reed–Sternberg cells and often affecting lymph nodes.
D. Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
E. Leukemia and Lymphoma Research
Leukemia and Lymphoma Research is a UK-based medical research charity dedicated to improving the diagnosis, treatment, and prevention of blood cancers such as leukemia and lymphoma.
F. None of above. chosen

Statements (64)

Predicate	Object
instanceOf	hematologic malignancy ⓘ leukemia ⓘ lymphoproliferative disorder ⓘ non-Hodgkin lymphoma ⓘ
affectsCellType	B lymphocyte ⓘ linked to: B lymphocytes
affectsSystem	blood ⓘ bone marrow ⓘ
associatedWithGeneMutation	NOTCH1 mutation ⓘ SF3B1 mutation ⓘ TP53 mutation ⓘ
associatedWithGeneticAbnormality	del(11q) ⓘ del(13q14) ⓘ del(17p) ⓘ trisomy 12 ⓘ
canBe	asymptomatic at diagnosis ⓘ
canTransformTo	diffuse large B-cell lymphoma ⓘ
commonLaboratoryFinding	absolute lymphocytosis ⓘ anemia ⓘ thrombocytopenia ⓘ
commonSign	hepatomegaly ⓘ lymphadenopathy ⓘ splenomegaly ⓘ
commonSymptom	fatigue ⓘ night sweats ⓘ recurrent infections ⓘ unintentional weight loss ⓘ
complication	autoimmune hemolytic anemia ⓘ hypogammaglobulinemia ⓘ immune thrombocytopenia ⓘ increased infection risk ⓘ
diagnosedBy	complete blood count ⓘ flow cytometry immunophenotyping ⓘ peripheral blood smear ⓘ
epidemiologyRegion	most common leukemia in Western countries ⓘ
hasAbbreviation	CLL ⓘ linked to: chronic lymphocytic leukemia
hasFullName	chronic lymphocytic leukemia ⓘ
hasICD10Code	C91.1 ⓘ
hasImmunophenotypeMarker	CD19 ⓘ CD20 dim ⓘ CD23 ⓘ CD5-positive B cells ⓘ surface immunoglobulin dim ⓘ
hasPrognosticMarker	IGHV mutation status ⓘ TP53 disruption ⓘ beta-2 microglobulin level ⓘ
isCharacterizedBy	accumulation of monoclonal B cells ⓘ bone marrow infiltration ⓘ lymph node enlargement ⓘ lymphocytosis ⓘ slow progression ⓘ
mayRequire	bone marrow biopsy ⓘ
primaryTreatmentOption	watchful waiting ⓘ
riskFactor	advanced age ⓘ family history of CLL ⓘ
sexPredominance	more common in males ⓘ
transformationSyndromeName	Richter transformation ⓘ
treatmentOption	BCL2 inhibitor ⓘ Bruton tyrosine kinase inhibitor ⓘ allogeneic stem cell transplantation ⓘ anti-CD20 monoclonal antibody ⓘ chemoimmunotherapy ⓘ
typicalCourse	indolent ⓘ
typicalOnsetAge	>=60 years ⓘ
typicalOnsetAgeGroup	older adults ⓘ

How these facts were elicited

Referenced by (14)

Full triples — surface form annotated when it differs from this entity's canonical label.

MabThera → indication → chronic lymphocytic leukemia ⓘ

Bruton tyrosine kinase → associatedWithDisease → chronic lymphocytic leukemia ⓘ

Ruxience → isUsedForTreatmentOf → chronic lymphocytic leukemia ⓘ

Riabni → hasIndication → chronic lymphocytic leukemia ⓘ

BTK → associatedWithDisease → chronic lymphocytic leukemia ⓘ

Venclexta → indication → small lymphocytic lymphoma ⓘ