SH3 domain
E1549333
UNEXPLORED
The SH3 domain is a small protein module found in many signaling and cytoskeletal proteins that typically binds proline-rich sequences to mediate protein–protein interactions.
All labels observed (1)
| Label | Occurrences |
|---|---|
| SH3 domain canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690575 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: SH3 domain Context triple: [BTK, hasDomain, SH3 domain]
-
A.
Notch intracellular domain
The Notch intracellular domain is the cleaved, cytoplasmic fragment of the Notch receptor that translocates to the nucleus to regulate gene transcription in the Notch signaling pathway.
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B.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
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C.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
D.
LIN-12/Notch repeats
LIN-12/Notch repeats are a series of conserved extracellular protein motifs characteristic of Notch family receptors that mediate protein–protein interactions crucial for Notch signaling.
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E.
Cdh1
Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: SH3 domain Target entity description: The SH3 domain is a small protein module found in many signaling and cytoskeletal proteins that typically binds proline-rich sequences to mediate protein–protein interactions.
-
A.
Notch intracellular domain
The Notch intracellular domain is the cleaved, cytoplasmic fragment of the Notch receptor that translocates to the nucleus to regulate gene transcription in the Notch signaling pathway.
-
B.
Ezrin
Ezrin is a Canadian music producer and songwriter best known for his work on landmark rock albums by artists such as Pink Floyd, Alice Cooper, and Kiss.
-
C.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
D.
LIN-12/Notch repeats
LIN-12/Notch repeats are a series of conserved extracellular protein motifs characteristic of Notch family receptors that mediate protein–protein interactions crucial for Notch signaling.
-
E.
Cdh1
Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.