|
gptkbp:instanceOf
|
gptkb:first-generation_antihistamine
gptkb:drug
gptkb:antihistamine
|
|
gptkbp:approvedBy
|
1946
|
|
gptkbp:ATCCode
|
R06AA02
|
|
gptkbp:brand
|
gptkb:Benadryl
gptkb:Nytol
|
|
gptkbp:canCauseDependence
|
no
|
|
gptkbp:CASNumber
|
58-73-1
|
|
gptkbp:chemicalFormula
|
gptkb:C17H21NO
|
|
gptkbp:contraindication
|
gptkb:glaucoma
asthma
enlarged prostate
|
|
gptkbp:discoveredBy
|
gptkb:George_Rieveschl
|
|
gptkbp:discoveredIn
|
1943
|
|
gptkbp:eliminationHalfLife
|
2.4–9.3 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:MAO_inhibitors
gptkb:CNS_depressants
|
|
gptkbp:isAvailableAsGeneric
|
yes
|
|
gptkbp:IUPACName
|
2-(diphenylmethoxy)-N,N-dimethylethanamine
|
|
gptkbp:legalStatus
|
OTC (over-the-counter)
|
|
gptkbp:mechanismOfAction
|
H1 receptor antagonist
anticholinergic
|
|
gptkbp:MeSH_ID
|
D004008
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
255.36 g/mol
|
|
gptkbp:overdoseSymptoms
|
gptkb:death
gptkb:arrhythmia
delirium
seizures
hallucinations
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
3100
CHEMBL651
DB01075
|
|
gptkbp:recreationalActivity
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
topical
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
confusion
constipation
dizziness
blurred vision
drowsiness
dry mouth
urinary retention
|
|
gptkbp:UNII
|
8GTS82S83M
|
|
gptkbp:usedFor
|
insomnia
cough suppression
extrapyramidal symptoms
parkinsonism
allergy relief
motion sickness
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Cough_Syrup
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Diphenhydramine
|