Diphenhydramine

GPTKB entity

Statements (60)
Predicate Object
gptkbp:instanceOf gptkb:drug
antihistamine
first-generation antihistamine
gptkbp:approvedBy 1946
gptkbp:ATCCode R06AA02
gptkbp:brand gptkb:Benadryl
gptkb:Nytol
gptkbp:canCauseDependence no
gptkbp:CASNumber 58-73-1
gptkbp:chemicalFormula gptkb:C17H21NO
gptkbp:contraindication asthma
glaucoma
enlarged prostate
gptkbp:discoveredBy gptkb:George_Rieveschl
gptkbp:discoveredIn 1943
gptkbp:eliminationHalfLife 2.4–9.3 hours
gptkbp:excretion urine
https://www.w3.org/2000/01/rdf-schema#label Diphenhydramine
gptkbp:interactsWith gptkb:beer
gptkb:MAO_inhibitors
gptkb:CNS_depressants
gptkbp:isAvailableAsGeneric yes
gptkbp:IUPACName 2-(diphenylmethoxy)-N,N-dimethylethanamine
gptkbp:legalStatus OTC (over-the-counter)
gptkbp:mechanismOfAction H1 receptor antagonist
anticholinergic
gptkbp:MeSH_ID D004008
gptkbp:metabolism liver
gptkbp:molecularWeight 255.36 g/mol
gptkbp:overdoseSymptoms gptkb:arrhythmia
death
delirium
seizures
hallucinations
gptkbp:pregnancyCategory B (US)
gptkbp:PubChem_CID 3100
CHEMBL651
DB01075
gptkbp:recreationalActivity yes
gptkbp:routeOfAdministration oral
topical
intramuscular
intravenous
gptkbp:sideEffect confusion
constipation
dizziness
blurred vision
drowsiness
dry mouth
urinary retention
gptkbp:UNII 8GTS82S83M
gptkbp:usedFor insomnia
cough suppression
extrapyramidal symptoms
parkinsonism
allergy relief
motion sickness
gptkbp:WHOModelListOfEssentialMedicines true
gptkbp:bfsParent gptkb:Cough_syrup
gptkbp:bfsLayer 6