|
gptkbp:instanceOf
|
gptkb:drug
iron chelator
|
|
gptkbp:approvedBy
|
gptkb:FDA
1960s
|
|
gptkbp:ATCCode
|
gptkb:V03AC01
|
|
gptkbp:brand
|
gptkb:Desferal
|
|
gptkbp:CASNumber
|
70-51-9
|
|
gptkbp:cause
|
gptkb:acute_respiratory_distress_syndrome
neurotoxicity
injection site reactions
|
|
gptkbp:chemicalFormula
|
C25H48N6O8
|
|
gptkbp:contraindication
|
severe renal impairment
anuria
|
|
gptkbp:discoveredBy
|
gptkb:Ciba-Geigy
|
|
gptkbp:eliminatedIn
|
renal
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Desferoxamine
|
|
gptkbp:isNotEffectiveFor
|
lead poisoning
copper poisoning
|
|
gptkbp:KEGGID
|
D00110
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:listedOn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:mechanismOfAction
|
binds free iron
forms ferrioxamine complex
|
|
gptkbp:MedlinePlusID
|
a682193
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
560.7 g/mol
|
|
gptkbp:origin
|
Streptomyces pilosus (bacterial source)
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
gptkb:DB00746
2973
CHEMBL1201
|
|
gptkbp:routeOfAdministration
|
intramuscular
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
hearing loss
hypotension
allergic reactions
visual disturbances
growth retardation
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:UNII
|
J06Y7MXW4D
|
|
gptkbp:usedFor
|
treatment of chronic iron overload
treatment of acute iron poisoning
treatment of aluminum toxicity
|
|
gptkbp:usedIn
|
gptkb:anemia
sideroblastic anemia
dialysis-related aluminum overload
transfusion-dependent anemias
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Deferoxamine
|
|
gptkbp:bfsLayer
|
6
|