|
gptkbp:instanceOf
|
gptkb:drug
iron chelator
|
|
gptkbp:approvedBy
|
gptkb:FDA
1968
|
|
gptkbp:ATCCode
|
gptkb:V03AC01
|
|
gptkbp:brand
|
gptkb:Desferal
|
|
gptkbp:CASNumber
|
70-51-9
|
|
gptkbp:cause
|
gptkb:mucormycosis
Yersinia infections
|
|
gptkbp:chemicalFormula
|
linear trihydroxamic acid
|
|
gptkbp:color
|
white to off-white powder
|
|
gptkbp:contraindication
|
severe renal impairment
|
|
gptkbp:discoveredBy
|
gptkb:Ciba-Geigy
|
|
gptkbp:eliminationHalfLife
|
20-30 minutes
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:hasMolecularFormula
|
C25H48N6O8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Deferoxamine
|
|
gptkbp:KEGGID
|
gptkb:D07810
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds free iron to form ferrioxamine
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
560.7 g/mol
|
|
gptkbp:origin
|
Streptomyces pilosus (bacterial fermentation product)
|
|
gptkbp:pregnancyCategory
|
C (US)
B3 (Australia)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEBI:4356
gptkb:DB00746
2973
2868
|
|
gptkbp:routeOfAdministration
|
intramuscular
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
gptkb:acute_respiratory_distress_syndrome
hearing loss
hypotension
allergic reactions
visual disturbances
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:storage
|
store at 2-8°C
|
|
gptkbp:synonym
|
gptkb:DFO
gptkb:Desferoxamine
gptkb:Desferrioxamine
|
|
gptkbp:UNII
|
J06Y7MXW4D
|
|
gptkbp:usedFor
|
treatment of chronic iron overload
treatment of acute iron poisoning
treatment of aluminum toxicity
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Antidotes
gptkb:Antidote
|
|
gptkbp:bfsLayer
|
5
|