DFMO

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkb:drug
gptkbp:approvedBy gptkb:European_Union
gptkb:United_States
1990
gptkbp:ATCCode P01CX03
gptkbp:boilingPoint decomposes
gptkbp:brand gptkb:Ornidyl
gptkb:Vaniqa
gptkbp:CASNumber 700-13-0
gptkbp:color white
gptkbp:contraindication pregnancy
breastfeeding
gptkbp:developedBy Merrell Dow
gptkbp:discoveredBy Irwin H. S. Gelbard
gptkbp:eliminatedIn renal
gptkbp:form crystalline powder
gptkbp:halfLife 3 hours
gptkbp:hasInChIKey QKQKRCQVRVQKQR-REOHCLBHSA-N
gptkbp:hasMolecularFormula C6H12F2N2O2
gptkbp:hasSMILES C(C[C@@H](C(=O)O)N)N(CF)F
gptkbp:hasUNII 4I6E4J345W
https://www.w3.org/2000/01/rdf-schema#label DFMO
gptkbp:IUPACName (2R)-2-difluoromethylornithine
gptkbp:KEGGID D07913
gptkbp:legalStatus prescription only
off-patent
Rx-only
gptkbp:listedOn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:mechanismOfAction irreversible inhibitor of ornithine decarboxylase
gptkbp:meltingPoint 220-222 °C
gptkbp:molecularWeight 182.17 g/mol
gptkbp:pregnancyCategory C (US)
B3 (AU)
gptkbp:PubChem_CID CHEMBL1387
30815
DB01140
gptkbp:routeOfAdministration topical
intravenous
gptkbp:sideEffect gptkb:anemia
diarrhea
hearing loss
seizures
gastrointestinal disturbances
gptkbp:solubility water soluble
gptkbp:synonym Eflornithine
α-difluoromethylornithine
gptkbp:target gptkb:ornithine_decarboxylase
gptkbp:therapeuticArea gptkb:disease
dermatology
gptkbp:usedFor treatment of African trypanosomiasis
treatment of facial hirsutism
gptkbp:bfsParent gptkb:eflornithine
gptkbp:bfsLayer 6