|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
1976
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:C07AB03
|
|
gptkbp:bioavailability
|
40-50%
|
|
gptkbp:brand
|
gptkb:Tenormin
|
|
gptkbp:CASNumber
|
gptkb:29122-68-7
|
|
gptkbp:contraindication
|
heart block
cardiogenic shock
sinus bradycardia
overt cardiac failure
|
|
gptkbp:drugClass
|
beta blocker
antianginal agent
antiarrhythmic agent
antihypertensive agent
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:halfLife
|
6-7 hours
|
|
gptkbp:hasDrugBankURL
|
https://go.drugbank.com/drugs/DB00124
|
|
gptkbp:hasGenericAvailability
|
yes
|
|
gptkbp:hasInChIKey
|
METKIMKYRPQLGS-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C14H22N2O3
|
|
gptkbp:hasSMILES
|
CC(C)NCC(COC1=CC=CC=C1C(=O)N)O
|
|
gptkbp:hasUNII
|
50VV3VW0TI
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00124
|
|
gptkbp:indication
|
myocardial infarction
hypertension
angina pectoris
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
beta-1 adrenergic receptor blocker
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
266.336 g/mol
|
|
gptkbp:name
|
gptkb:Atenolol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:proteinBinding
|
6-16%
|
|
gptkbp:PubChem_CID
|
gptkb:D00222
2249
CHEMBL26
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
dizziness
fatigue
bradycardia
cold extremities
|
|
gptkbp:synonym
|
gptkb:Atenololum
4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetamide
|
|
gptkbp:target
|
beta-1 adrenergic receptor
|
|
gptkbp:bfsParent
|
gptkb:adenosine_5'-monophosphate
|
|
gptkbp:bfsLayer
|
7
|