|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
1982
|
|
gptkbp:ATCCode
|
A10AB01
|
|
gptkbp:bioavailability
|
Varies by route
|
|
gptkbp:CASNumber
|
11061-68-0
|
|
gptkbp:color
|
Clear
|
|
gptkbp:contraindication
|
gptkb:Hypersensitivity_to_insulin
Hypoglycemia
|
|
gptkbp:drugClass
|
Hormones
Insulins
Regulates carbohydrate, fat, and protein metabolism
|
|
gptkbp:eliminationHalfLife
|
4-6 minutes
|
|
gptkbp:form
|
Solution for injection
|
|
gptkbp:halfLife
|
4-6 minutes
|
|
gptkbp:hasAdministrationFrequency
|
Multiple times daily
|
|
gptkbp:hasInChIKey
|
AEMKQIXGQGCWCF-CCEZHUSRSA-N
|
|
gptkbp:hasMolecularFormula
|
C257H383N65O77S6
|
|
gptkbp:hasPatent
|
US4382932A
|
|
gptkbp:hasPharmacokinetics
|
Onset 30-60 min, peak 2-4 h, duration 6-8 h
|
|
gptkbp:hasSMILES
|
C[C@H](N)C(=O)O...
|
|
gptkbp:hasStorageCondition
|
Refrigerate
|
|
gptkbp:hasStorageTemperature
|
2-8°C
|
|
gptkbp:hasUNII
|
1F7A44V6OU
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00065
|
|
gptkbp:indication
|
gptkb:Diabetes_mellitus
|
|
gptkbp:legalStatus
|
Prescription only
|
|
gptkbp:manufacturer
|
gptkb:Novo_Nordisk
gptkb:Eli_Lilly_and_Company
gptkb:Sanofi
|
|
gptkbp:mechanismOfAction
|
Binds to insulin receptor and stimulates glucose uptake
|
|
gptkbp:metabolism
|
Liver, kidney, muscle
|
|
gptkbp:molecularWeight
|
5808.0
|
|
gptkbp:name
|
gptkb:Insulin_(human)
|
|
gptkbp:originatedIn
|
Recombinant DNA technology
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
Low
|
|
gptkbp:PubChem_CID
|
gptkb:DB00065
101896409
D04468
CHEMBL1201613
|
|
gptkbp:routeOfAdministration
|
Intramuscular
Intravenous
Subcutaneous
|
|
gptkbp:sideEffect
|
gptkb:Lipodystrophy
Allergic reactions
Hypoglycemia
|
|
gptkbp:status
|
FDA approved
|
|
gptkbp:synonym
|
gptkb:Actrapid
gptkb:Humulin_R
gptkb:Novolin_R
Regular insulin
|
|
gptkbp:target
|
gptkb:Insulin_receptor
|
|
gptkbp:therapeuticArea
|
Endocrinology
|
|
gptkbp:bfsParent
|
gptkb:infliximab
|
|
gptkbp:bfsLayer
|
6
|