Cystic fibrosis transmembrane conductance regulator (CFTR) modulators
URI: https://gptkb.org/entity/Cystic_fibrosis_transmembrane_conductance_regulator_%28CFTR%29_modulators
GPTKB entity
Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:Symdeko
|
| gptkbp:activities |
enhance CFTR function
|
| gptkbp:appointed_by |
oral medication
|
| gptkbp:approves |
gptkb:FDA
|
| gptkbp:availability |
prescription only
|
| gptkbp:clinical_trial |
Phase 3
chronic management of cystic fibrosis |
| gptkbp:contraindication |
hypersensitivity to components
|
| gptkbp:developed_by |
gptkb:Vertex_Pharmaceuticals
|
| gptkbp:dosage_form |
oral
|
| gptkbp:formulation |
tablets
powder for oral suspension |
| https://www.w3.org/2000/01/rdf-schema#label |
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators
|
| gptkbp:impact |
healthcare costs
mortality rates hospitalization rates quality-adjusted life years (QAL Ys) |
| gptkbp:improves |
lung function
|
| gptkbp:includes |
gptkb:ivacaftor
gptkb:lumacaftor gptkb:tezacaftor |
| gptkbp:increased |
quality of life
|
| gptkbp:indication |
cystic fibrosis with specific mutations
|
| gptkbp:interacts_with |
CY P3 A inducers
CY P3 A inhibitors |
| gptkbp:invention |
patented
|
| gptkbp:is_monitored_by |
adverse effects
pulmonary function tests liver function tests |
| gptkbp:is_used_for |
treatment of cystic fibrosis
|
| gptkbp:marketed_as |
gptkb:Kalydeco
gptkb:Orkambi gptkb:Symdeko gptkb:Trikafta |
| gptkbp:provides_information_on |
recommended for use in eligible patients
|
| gptkbp:reduces |
pulmonary exacerbations
|
| gptkbp:research_areas |
patient adherence
combination therapies long-term outcomes gene therapy for cystic fibrosis health economics of CFTR modulators |
| gptkbp:research_focus |
new CFTR modulators
|
| gptkbp:side_effect |
headache
nausea abdominal pain diarrhea |
| gptkbp:target_audience |
patients with cystic fibrosis
|
| gptkbp:targets |
CFTR protein
|
| gptkbp:used_in |
clinical trials
|