Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
combination drug |
| gptkbp:activeIngredient |
gptkb:ivacaftor
gptkb:lumacaftor |
| gptkbp:approvalYear |
2015
|
| gptkbp:approvedBy |
patients with two copies of the F508del mutation in the CFTR gene
|
| gptkbp:ATCCode |
R07AX30
|
| gptkbp:countryOfOperation |
gptkb:European_Union
gptkb:United_States |
| gptkbp:drugClass |
CFTR corrector
CFTR potentiator |
| gptkbp:form |
gptkb:tablet
granules |
| https://www.w3.org/2000/01/rdf-schema#label |
Orkambi
|
| gptkbp:indication |
cystic fibrosis
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:manufacturer |
gptkb:Vertex_Pharmaceuticals
|
| gptkbp:mechanismOfAction |
CFTR modulator
|
| gptkbp:pregnancyCategory |
B (US)
|
| gptkbp:prescriptionStatus |
Rx-only
|
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
diarrhea shortness of breath upper respiratory tract infection increased liver enzymes |
| gptkbp:bfsParent |
gptkb:Vertex_Pharmaceuticals
|
| gptkbp:bfsLayer |
5
|