Statements (144)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
gptkb:Cyclin-dependent_kinase |
| gptkbp:activation_mechanism |
Binding to cyclins
|
| gptkbp:activator |
gptkb:Cyclin-dependent_kinase
|
| gptkbp:associated_with |
cell cycle progression
Cell cycle progression |
| gptkbp:challenges |
Cancer progression
cancer progression |
| gptkbp:clinical_trial |
Target for cancer drugs
|
| gptkbp:discovered_by |
1970s
|
| gptkbp:example |
gptkb:CDK6
gptkb:CDK1 gptkb:CDK2 CDK4 CDK12 CDK13 CDK14 CDK15 CDK16 CDK17 CDK18 CDK19 CDK20 CDK21 CDK22 CDK23 CDK24 CDK25 CDK26 CDK27 CDK28 CDK29 CDK30 CDK31 CDK32 CDK33 CDK34 CDK35 CDK36 CDK37 CDK38 CDK39 CDK40 CDK41 CDK42 CDK43 CDK44 CDK45 CDK46 CDK47 CDK48 CDK49 CDK50 CDK7 CDK9 |
| gptkbp:family |
gptkb:CDK_family
|
| gptkbp:function |
Regulates the cell cycle
phosphorylation of serine and threonine residues regulate the cell cycle |
| gptkbp:fuselage_material |
peptides
p53 protein proteins Histone proteins Retinoblastoma protein |
| gptkbp:has_family |
MAPK family
AGC kinase family CAMK family PKA family PKC family Rho kinase family CK1 family |
| gptkbp:has_role |
cellular homeostasis
cellular metabolism gene expression cellular response to stress |
| https://www.w3.org/2000/01/rdf-schema#label |
Cyclin-dependent kinase
|
| gptkbp:inhibition_mechanism |
Phosphorylation by CDK inhibitors
|
| gptkbp:initiated_by |
growth factors
hormones p21 CDK inhibitor p16 p27 protein phosphatases CDK inhibitor proteins |
| gptkbp:involved_in |
metabolism
apoptosis cell cycle regulation Cellular signaling cellular signaling pathways |
| gptkbp:is_associated_with |
gptkb:Oncology
gptkb:neurodegenerative_diseases |
| gptkbp:is_essential_for |
gptkb:developers
cell differentiation cell growth immune response |
| gptkbp:is_found_in |
eukaryotic cells
prokaryotic cells |
| gptkbp:is_involved_in |
gptkb:embryonic_development
cellular stress response developmental processes muscle contraction neurotransmitter release signal transduction pathways wound healing cellular aging tissue regeneration neural development organogenesis immune cell activation cellular signaling pathways cellular communication vascular development signal amplification cellular repair mechanisms stem cell differentiation |
| gptkbp:is_part_of |
regulatory networks
cellular pathways enzyme cascades signal transduction complexes |
| gptkbp:is_regulated_by |
feedback mechanisms
post-translational modifications allosteric regulation |
| gptkbp:is_studied_in |
molecular biology
biochemistry cell biology pharmacology |
| gptkbp:is_targeted_at |
drugs
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:regulatory_compliance |
Cell cycle checkpoints
cyclin levels |
| gptkbp:research_focus |
Cancer therapy
|
| gptkbp:role |
cell signaling
Phosphorylation of target proteins phosphorylation of target proteins |
| gptkbp:targets |
gptkb:retinoblastoma_protein_(Rb)
p53 protein |
| gptkbp:type |
Serine/threonine kinase
|
| gptkbp:type_of |
gptkb:CDK6
gptkb:CDK1 gptkb:CDK2 CDK4 |
| gptkbp:bfsParent |
gptkb:Momelotinib
|
| gptkbp:bfsLayer |
5
|